FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972089648> ?p ?o ?g. }

• W1972089648 endingPage "2255" @default.
• W1972089648 startingPage "2249" @default.
• W1972089648 abstract "In a recent study, iron chelation with deferoxamine led to improvement of endothelial dysfunction in patients with coronary artery disease. We tested the hypothesis that decreasing circulating iron stores might improve vascular dysfunction in patients with type 2 diabetes and increased serum ferritin concentration.A total of 28 type 2 diabetic male patients with serum ferritin levels >200 ng/ml ( approximately 18% of consecutive type 2 diabetic men attending our outpatient clinic) were randomized to iron depletion (three extractions of 500 ml blood at 2-week intervals; group 1A) or to observation (group 1B). C282Y mutation was absent in all patients. Vascular reactivity (high-resolution external ultrasound) was evaluated at baseline and at 4 and 12 months thereafter. The two groups of patients were matched for age, BMI, pharmacological treatment, and chronic diabetic complications.Endothelium-dependent vasodilation remained essentially unchanged in both groups of patients. In contrast, the vasodilation induced by glyceryl trinitrate (GTN) improved significantly after iron depletion (P = 0.006). These changes occurred in parallel to decreases in transferrin saturation index and HbA(1c) levels (-0.6%, P < 0.05) only in group 1A patients. The best predictor of the modifications in endothelium-independent vasodilation was the change in HbA(1c) levels. Changes in endothelium-independent vasodilation also correlated with the change in serum ferritin (r = -0.45, P = 0.04). At 12 months, transferrin saturation index and GTN-induced vasodilation returned to values similar to those at baseline in both groups of subjects.Iron depletion improves vascular dysfunction in type 2 diabetic patients with high ferritin concentrations. The mechanisms by which these changes occur should be further investigated." @default.
• W1972089648 created "2016-06-24" @default.
• W1972089648 creator A5007880285 @default.
• W1972089648 creator A5017184853 @default.
• W1972089648 creator A5046812329 @default.
• W1972089648 creator A5070121419 @default.
• W1972089648 creator A5081449842 @default.
• W1972089648 creator A5088545221 @default.
• W1972089648 date "2002-12-01" @default.
• W1972089648 modified "2023-09-29" @default.
• W1972089648 title "Blood Letting in High-Ferritin Type 2 Diabetes" @default.
• W1972089648 cites W1484535674 @default.
• W1972089648 cites W1967923317 @default.
• W1972089648 cites W1969776575 @default.
• W1972089648 cites W1975974235 @default.
• W1972089648 cites W1984334088 @default.
• W1972089648 cites W1993387626 @default.
• W1972089648 cites W1994895968 @default.
• W1972089648 cites W2006984835 @default.
• W1972089648 cites W2011677357 @default.
• W1972089648 cites W2018020365 @default.
• W1972089648 cites W2020631276 @default.
• W1972089648 cites W2022574364 @default.
• W1972089648 cites W2023941312 @default.
• W1972089648 cites W2035433779 @default.
• W1972089648 cites W2047525244 @default.
• W1972089648 cites W2057147472 @default.
• W1972089648 cites W2058137293 @default.
• W1972089648 cites W2060339082 @default.
• W1972089648 cites W2063506869 @default.
• W1972089648 cites W2064809465 @default.
• W1972089648 cites W2074712105 @default.
• W1972089648 cites W2077130091 @default.
• W1972089648 cites W2084923138 @default.
• W1972089648 cites W2088797639 @default.
• W1972089648 cites W2091219945 @default.
• W1972089648 cites W2096569639 @default.
• W1972089648 cites W2102680817 @default.
• W1972089648 cites W2109996595 @default.
• W1972089648 cites W2113083707 @default.
• W1972089648 cites W2119012743 @default.
• W1972089648 cites W2130870274 @default.
• W1972089648 cites W2131210225 @default.
• W1972089648 cites W2138236516 @default.
• W1972089648 cites W2144168692 @default.
• W1972089648 cites W2157091064 @default.
• W1972089648 cites W2163940587 @default.
• W1972089648 cites W2167311408 @default.
• W1972089648 cites W2169190847 @default.
• W1972089648 cites W2257343047 @default.
• W1972089648 cites W2315618879 @default.
• W1972089648 cites W2320338000 @default.
• W1972089648 cites W2323688857 @default.
• W1972089648 cites W2341006855 @default.
• W1972089648 cites W2410551540 @default.
• W1972089648 cites W2617392052 @default.
• W1972089648 cites W4236017105 @default.
• W1972089648 cites W4249091534 @default.
• W1972089648 cites W4252076702 @default.
• W1972089648 cites W4253650722 @default.
• W1972089648 cites W969915667 @default.
• W1972089648 doi "https://doi.org/10.2337/diacare.25.12.2249" @default.
• W1972089648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12453969" @default.
• W1972089648 hasPublicationYear "2002" @default.
• W1972089648 type Work @default.
• W1972089648 sameAs 1972089648 @default.
• W1972089648 citedByCount "78" @default.
• W1972089648 countsByYear W19720896482012 @default.
• W1972089648 countsByYear W19720896482013 @default.
• W1972089648 countsByYear W19720896482014 @default.
• W1972089648 countsByYear W19720896482015 @default.
• W1972089648 countsByYear W19720896482016 @default.
• W1972089648 countsByYear W19720896482017 @default.
• W1972089648 countsByYear W19720896482018 @default.
• W1972089648 countsByYear W19720896482019 @default.
• W1972089648 countsByYear W19720896482020 @default.
• W1972089648 countsByYear W19720896482021 @default.
• W1972089648 countsByYear W19720896482022 @default.
• W1972089648 countsByYear W19720896482023 @default.
• W1972089648 crossrefType "journal-article" @default.
• W1972089648 hasAuthorship W1972089648A5007880285 @default.
• W1972089648 hasAuthorship W1972089648A5017184853 @default.
• W1972089648 hasAuthorship W1972089648A5046812329 @default.
• W1972089648 hasAuthorship W1972089648A5070121419 @default.
• W1972089648 hasAuthorship W1972089648A5081449842 @default.
• W1972089648 hasAuthorship W1972089648A5088545221 @default.
• W1972089648 hasBestOaLocation W19720896481 @default.
• W1972089648 hasConcept C120770815 @default.
• W1972089648 hasConcept C126322002 @default.
• W1972089648 hasConcept C134018914 @default.
• W1972089648 hasConcept C141071460 @default.
• W1972089648 hasConcept C153852466 @default.
• W1972089648 hasConcept C164705383 @default.
• W1972089648 hasConcept C2776672577 @default.
• W1972089648 hasConcept C2776992346 @default.
• W1972089648 hasConcept C2777180221 @default.
• W1972089648 hasConcept C2777466421 @default.
• W1972089648 hasConcept C2777660278 @default.

• next