FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972103411> ?p ?o ?g. }

• W1972103411 endingPage "195" @default.
• W1972103411 startingPage "187" @default.
• W1972103411 abstract "One of the notable features of Alzheimer's disease (AD) is the overabundance of beta-amyloid peptides in brain fluids, leading to the formation and deposition of insoluble amyloid plaques. Previous work in this lab demonstrates that the normal choroid plexus, a primary component of the blood–cerebrospinal fluid barrier, has the capacity to remove beta-amyloid from the cerebrospinal fluid, potentially preventing the formation of beta-amyloid plaques. The purpose of this work was to determine whether the choroid plexus and/or the brain capillaries, a primary component of the blood–brain barrier, possessed the capacity to produce or degrade beta-amyloid peptides. Using quantitative real-time RT-PCR, immunodetection and enzyme activity assays, we demonstrated the presence in brain barriers of several key enzymes involved in beta-amyloid production, namely, amyloid precursor protein and beta-secretase, and in beta-amyloid metabolism and alternate processing, such as insulin degrading enzyme, endothelin-converting enzyme-1, neprilysin and alpha-secretase. Furthermore, beta-amyloid presence, in the absence of its application in culture media, was detected in an immortalized choroidal epithelial cell line, known as Z310 cells. The ability of the choroid plexus to produce and degrade beta-amyloid, in addition to its transport function, suggests a vital role of this tissue in maintaining beta-amyloid homeostasis. Disruption of this homeostasis due to aging, injury or toxicant exposure may contribute to accumulation of beta-amyloid peptides in the brain fluids, leading to AD." @default.
• W1972103411 created "2016-06-24" @default.
• W1972103411 creator A5015155907 @default.
• W1972103411 creator A5042747199 @default.
• W1972103411 creator A5087384896 @default.
• W1972103411 date "2007-03-01" @default.
• W1972103411 modified "2023-10-03" @default.
• W1972103411 title "Macromolecules involved in production and metabolism of beta-amyl oid at the brain barriers" @default.
• W1972103411 cites W1021818602 @default.
• W1972103411 cites W1909683981 @default.
• W1972103411 cites W1968026951 @default.
• W1972103411 cites W1968549312 @default.
• W1972103411 cites W1975849504 @default.
• W1972103411 cites W1995793150 @default.
• W1972103411 cites W1996363835 @default.
• W1972103411 cites W1997822484 @default.
• W1972103411 cites W2003686230 @default.
• W1972103411 cites W2004782459 @default.
• W1972103411 cites W2008390180 @default.
• W1972103411 cites W2026237615 @default.
• W1972103411 cites W2028403300 @default.
• W1972103411 cites W2031654879 @default.
• W1972103411 cites W2040728312 @default.
• W1972103411 cites W2041851050 @default.
• W1972103411 cites W2042923446 @default.
• W1972103411 cites W2045800054 @default.
• W1972103411 cites W2052679565 @default.
• W1972103411 cites W2065013860 @default.
• W1972103411 cites W2068631553 @default.
• W1972103411 cites W2074123947 @default.
• W1972103411 cites W2082504479 @default.
• W1972103411 cites W2083777537 @default.
• W1972103411 cites W2084073639 @default.
• W1972103411 cites W2084612470 @default.
• W1972103411 cites W2086278983 @default.
• W1972103411 cites W2087607022 @default.
• W1972103411 cites W2091087713 @default.
• W1972103411 cites W2091948332 @default.
• W1972103411 cites W2094031456 @default.
• W1972103411 cites W2095698264 @default.
• W1972103411 cites W2097873358 @default.
• W1972103411 cites W2106274713 @default.
• W1972103411 cites W2130695898 @default.
• W1972103411 cites W2134010906 @default.
• W1972103411 cites W2134256872 @default.
• W1972103411 cites W2143512237 @default.
• W1972103411 cites W2146443559 @default.
• W1972103411 cites W2169152986 @default.
• W1972103411 cites W2300509685 @default.
• W1972103411 cites W2311846732 @default.
• W1972103411 cites W2461139908 @default.
• W1972103411 cites W2468465792 @default.
• W1972103411 cites W4252045980 @default.
• W1972103411 cites W4254956505 @default.
• W1972103411 doi "https://doi.org/10.1016/j.brainres.2006.12.022" @default.
• W1972103411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1950938" @default.
• W1972103411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17276414" @default.
• W1972103411 hasPublicationYear "2007" @default.
• W1972103411 type Work @default.
• W1972103411 sameAs 1972103411 @default.
• W1972103411 citedByCount "33" @default.
• W1972103411 countsByYear W19721034112012 @default.
• W1972103411 countsByYear W19721034112013 @default.
• W1972103411 countsByYear W19721034112014 @default.
• W1972103411 countsByYear W19721034112015 @default.
• W1972103411 countsByYear W19721034112016 @default.
• W1972103411 countsByYear W19721034112017 @default.
• W1972103411 countsByYear W19721034112018 @default.
• W1972103411 countsByYear W19721034112020 @default.
• W1972103411 crossrefType "journal-article" @default.
• W1972103411 hasAuthorship W1972103411A5015155907 @default.
• W1972103411 hasAuthorship W1972103411A5042747199 @default.
• W1972103411 hasAuthorship W1972103411A5087384896 @default.
• W1972103411 hasBestOaLocation W19721034112 @default.
• W1972103411 hasConcept C104826730 @default.
• W1972103411 hasConcept C134018914 @default.
• W1972103411 hasConcept C142724271 @default.
• W1972103411 hasConcept C169760540 @default.
• W1972103411 hasConcept C179104552 @default.
• W1972103411 hasConcept C181199279 @default.
• W1972103411 hasConcept C185592680 @default.
• W1972103411 hasConcept C2776156579 @default.
• W1972103411 hasConcept C2776538271 @default.
• W1972103411 hasConcept C2777633098 @default.
• W1972103411 hasConcept C2778402981 @default.
• W1972103411 hasConcept C2779134260 @default.
• W1972103411 hasConcept C2779281246 @default.
• W1972103411 hasConcept C2779651940 @default.
• W1972103411 hasConcept C2780331951 @default.
• W1972103411 hasConcept C31705614 @default.
• W1972103411 hasConcept C36103677 @default.
• W1972103411 hasConcept C502032728 @default.
• W1972103411 hasConcept C529278444 @default.
• W1972103411 hasConcept C55493867 @default.
• W1972103411 hasConcept C71924100 @default.
• W1972103411 hasConcept C86803240 @default.
• W1972103411 hasConceptScore W1972103411C104826730 @default.
• W1972103411 hasConceptScore W1972103411C134018914 @default.

• next