Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972108144> ?p ?o ?g. }
- W1972108144 endingPage "2258" @default.
- W1972108144 startingPage "2253" @default.
- W1972108144 abstract "Glutathione (GSH), in addition to serving as a redox buffer in cellular environment, has been suggested as a modulator in metal regulation and homeostasis by metallothioneins (MTs). The interactions of MTs with both GSH and its oxidized form GSSG have been shown to govern the direction of metal transfer. Common methods for the determination of zinc release from MTs modulated by GSH/GSSG either involve radioactive species or enzymes or are labor-intensive. In this study, upon separation of Zn2+ from the reaction mixture of MTs and GSH with a centrifugal filter membrane, differential pulse voltammetry (DPV) was used for the Zn2+ quantification. The same approach is extended to the studies of metal transfer between Zn7MT with a GSH/GSSG mixture and that between Zn7MT with GSSG. The concomitant conversion between the free thiol and disulfide bonds was confirmed with UV-vis spectrophotometry. The results demonstrate that GSSG, GSH, and the GSH/GSSG mixture all modulate zinc release from Zn7MT. The percentage of zinc release increases in the order of GSH, GSSG, and the GSH/GSSG mixture. The new approach is demonstrated to be well suited for investigation of redox regulation of MT and its reaction with zinc-containing enzymes." @default.
- W1972108144 created "2016-06-24" @default.
- W1972108144 creator A5003719991 @default.
- W1972108144 creator A5034655909 @default.
- W1972108144 creator A5035648686 @default.
- W1972108144 creator A5040647242 @default.
- W1972108144 creator A5074129721 @default.
- W1972108144 date "2008-10-01" @default.
- W1972108144 modified "2023-09-24" @default.
- W1972108144 title "Voltammetric Investigation of Zinc Release from Metallothioneins Modulated by the Glutathione Redox Couple and Separated with a Porous Membrane" @default.
- W1972108144 cites W1540228280 @default.
- W1972108144 cites W1924266790 @default.
- W1972108144 cites W1967301498 @default.
- W1972108144 cites W1971892168 @default.
- W1972108144 cites W1980888582 @default.
- W1972108144 cites W1985115989 @default.
- W1972108144 cites W1995250796 @default.
- W1972108144 cites W2000917288 @default.
- W1972108144 cites W2004137721 @default.
- W1972108144 cites W2004590288 @default.
- W1972108144 cites W2005228313 @default.
- W1972108144 cites W2006370393 @default.
- W1972108144 cites W2013948741 @default.
- W1972108144 cites W2030996473 @default.
- W1972108144 cites W2031321313 @default.
- W1972108144 cites W2032074012 @default.
- W1972108144 cites W2038844755 @default.
- W1972108144 cites W2041596502 @default.
- W1972108144 cites W2041777125 @default.
- W1972108144 cites W2041784606 @default.
- W1972108144 cites W2042274919 @default.
- W1972108144 cites W2045382063 @default.
- W1972108144 cites W2050529727 @default.
- W1972108144 cites W2055403525 @default.
- W1972108144 cites W2069437899 @default.
- W1972108144 cites W2074214572 @default.
- W1972108144 cites W2077607967 @default.
- W1972108144 cites W2082202567 @default.
- W1972108144 cites W2082470605 @default.
- W1972108144 cites W2105452080 @default.
- W1972108144 cites W2154488584 @default.
- W1972108144 cites W2160606731 @default.
- W1972108144 cites W2212901299 @default.
- W1972108144 cites W2334558826 @default.
- W1972108144 cites W237886883 @default.
- W1972108144 cites W4245997153 @default.
- W1972108144 cites W4250221563 @default.
- W1972108144 cites W1976455096 @default.
- W1972108144 doi "https://doi.org/10.1002/elan.200804309" @default.
- W1972108144 hasPublicationYear "2008" @default.
- W1972108144 type Work @default.
- W1972108144 sameAs 1972108144 @default.
- W1972108144 citedByCount "4" @default.
- W1972108144 countsByYear W19721081442012 @default.
- W1972108144 countsByYear W19721081442013 @default.
- W1972108144 crossrefType "journal-article" @default.
- W1972108144 hasAuthorship W1972108144A5003719991 @default.
- W1972108144 hasAuthorship W1972108144A5034655909 @default.
- W1972108144 hasAuthorship W1972108144A5035648686 @default.
- W1972108144 hasAuthorship W1972108144A5040647242 @default.
- W1972108144 hasAuthorship W1972108144A5074129721 @default.
- W1972108144 hasConcept C147789679 @default.
- W1972108144 hasConcept C17525397 @default.
- W1972108144 hasConcept C178790620 @default.
- W1972108144 hasConcept C179104552 @default.
- W1972108144 hasConcept C181199279 @default.
- W1972108144 hasConcept C185592680 @default.
- W1972108144 hasConcept C20719415 @default.
- W1972108144 hasConcept C2777869211 @default.
- W1972108144 hasConcept C2779179908 @default.
- W1972108144 hasConcept C2779201268 @default.
- W1972108144 hasConcept C2779525745 @default.
- W1972108144 hasConcept C2781324293 @default.
- W1972108144 hasConcept C41625074 @default.
- W1972108144 hasConcept C43617362 @default.
- W1972108144 hasConcept C52859227 @default.
- W1972108144 hasConcept C535196362 @default.
- W1972108144 hasConcept C538909803 @default.
- W1972108144 hasConcept C544153396 @default.
- W1972108144 hasConcept C55493867 @default.
- W1972108144 hasConcept C55904794 @default.
- W1972108144 hasConceptScore W1972108144C147789679 @default.
- W1972108144 hasConceptScore W1972108144C17525397 @default.
- W1972108144 hasConceptScore W1972108144C178790620 @default.
- W1972108144 hasConceptScore W1972108144C179104552 @default.
- W1972108144 hasConceptScore W1972108144C181199279 @default.
- W1972108144 hasConceptScore W1972108144C185592680 @default.
- W1972108144 hasConceptScore W1972108144C20719415 @default.
- W1972108144 hasConceptScore W1972108144C2777869211 @default.
- W1972108144 hasConceptScore W1972108144C2779179908 @default.
- W1972108144 hasConceptScore W1972108144C2779201268 @default.
- W1972108144 hasConceptScore W1972108144C2779525745 @default.
- W1972108144 hasConceptScore W1972108144C2781324293 @default.
- W1972108144 hasConceptScore W1972108144C41625074 @default.
- W1972108144 hasConceptScore W1972108144C43617362 @default.
- W1972108144 hasConceptScore W1972108144C52859227 @default.
- W1972108144 hasConceptScore W1972108144C535196362 @default.
- W1972108144 hasConceptScore W1972108144C538909803 @default.