FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972114211> ?p ?o ?g. }

• W1972114211 endingPage "L183" @default.
• W1972114211 startingPage "L174" @default.
• W1972114211 abstract "Lung epithelial cells are important barriers in the respiratory system that provoke inflammatory responses through nuclear factor (NF)-κB activation to prevent pathogens from invading the body. Lipopolysaccharide (LPS) is a common pathogen-associated stimulus that activates IκB kinase (IKK) to regulate NF-κB-mediated inflammation through modulating nuclear translocation and phosphorylation of NF-κB. Previously, it was shown that Akt and the mammalian target of rapamycin (mTOR) are involved in the phosphorylation of IKK to activate NF-κB. Herein, we demonstrate that glutamine (GLN) modulated LPS-induced activation of NF-κB through the Akt/mTOR/IKK pathway in BEAS-2B cells. BEAS-2B cells in submerged culture were placed in medium containing different concentrations of GLN (0, 0.5, 1, and 2.5 mM) with 1 μg/ml LPS. Results showed that GLN deprivation induced phosphorylation of Akt/mTOR/IKK signaling, increased levels of NF-κB nuclear translocation and phosphorylated NF-κB, and upregulated NF-κB-dependent transcriptional activity, which was suppressed by GLN administration. Expressions of NF-κB-targeted genes were also reduced by supplemental GLN. GLN administration improved cell viability, whereas 0.5 mM GLN had a greater extent of inhibition on the Akt/mTOR/IKK/NF-κB signaling cascade. The inhibitory effects of GLN on NF-κB activation were also observed in cells cultured under air-liquid interface condition. These results indicate that GLN deprivation increased LPS-induced NF-κB activation and transcriptional activity, which was reversed by GLN administration. The findings provide potential mechanisms of GLN's modulation of LPS-induced NF-κB activation in lung epithelial cells and imply that maintaining a physiological concentration of GLN is essential in preventing LPS-induced lung inflammation." @default.
• W1972114211 created "2016-06-24" @default.
• W1972114211 creator A5009174406 @default.
• W1972114211 creator A5039685752 @default.
• W1972114211 creator A5060990393 @default.
• W1972114211 creator A5085227110 @default.
• W1972114211 date "2012-01-01" @default.
• W1972114211 modified "2023-10-13" @default.
• W1972114211 title "Glutamine modulates lipopolysaccharide-induced activation of NF-κB via the Akt/mTOR pathway in lung epithelial cells" @default.
• W1972114211 cites W1535444616 @default.
• W1972114211 cites W1555980866 @default.
• W1972114211 cites W1872118948 @default.
• W1972114211 cites W1896932421 @default.
• W1972114211 cites W1913519730 @default.
• W1972114211 cites W1930751460 @default.
• W1972114211 cites W1969457486 @default.
• W1972114211 cites W1974942240 @default.
• W1972114211 cites W1976499063 @default.
• W1972114211 cites W1985118687 @default.
• W1972114211 cites W2005759082 @default.
• W1972114211 cites W2008100923 @default.
• W1972114211 cites W2008314678 @default.
• W1972114211 cites W2010817360 @default.
• W1972114211 cites W2015472023 @default.
• W1972114211 cites W2020920210 @default.
• W1972114211 cites W2036285327 @default.
• W1972114211 cites W2038440449 @default.
• W1972114211 cites W2046728427 @default.
• W1972114211 cites W2054386531 @default.
• W1972114211 cites W2063126618 @default.
• W1972114211 cites W2067938485 @default.
• W1972114211 cites W2073000192 @default.
• W1972114211 cites W2085380653 @default.
• W1972114211 cites W2096555660 @default.
• W1972114211 cites W2101546320 @default.
• W1972114211 cites W2106515336 @default.
• W1972114211 cites W2117817795 @default.
• W1972114211 cites W2123226755 @default.
• W1972114211 cites W2129585918 @default.
• W1972114211 cites W2152936822 @default.
• W1972114211 cites W2156682968 @default.
• W1972114211 cites W2157109210 @default.
• W1972114211 cites W2157431224 @default.
• W1972114211 cites W2157448606 @default.
• W1972114211 cites W2163290123 @default.
• W1972114211 cites W2166655452 @default.
• W1972114211 cites W2169903226 @default.
• W1972114211 cites W2235485292 @default.
• W1972114211 cites W2335925695 @default.
• W1972114211 cites W4251121249 @default.
• W1972114211 doi "https://doi.org/10.1152/ajplung.00066.2011" @default.
• W1972114211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22003094" @default.
• W1972114211 hasPublicationYear "2012" @default.
• W1972114211 type Work @default.
• W1972114211 sameAs 1972114211 @default.
• W1972114211 citedByCount "34" @default.
• W1972114211 countsByYear W19721142112013 @default.
• W1972114211 countsByYear W19721142112014 @default.
• W1972114211 countsByYear W19721142112015 @default.
• W1972114211 countsByYear W19721142112016 @default.
• W1972114211 countsByYear W19721142112017 @default.
• W1972114211 countsByYear W19721142112018 @default.
• W1972114211 countsByYear W19721142112019 @default.
• W1972114211 countsByYear W19721142112020 @default.
• W1972114211 countsByYear W19721142112021 @default.
• W1972114211 countsByYear W19721142112022 @default.
• W1972114211 countsByYear W19721142112023 @default.
• W1972114211 crossrefType "journal-article" @default.
• W1972114211 hasAuthorship W1972114211A5009174406 @default.
• W1972114211 hasAuthorship W1972114211A5039685752 @default.
• W1972114211 hasAuthorship W1972114211A5060990393 @default.
• W1972114211 hasAuthorship W1972114211A5085227110 @default.
• W1972114211 hasConcept C100175707 @default.
• W1972114211 hasConcept C104317684 @default.
• W1972114211 hasConcept C11960822 @default.
• W1972114211 hasConcept C123298856 @default.
• W1972114211 hasConcept C134018914 @default.
• W1972114211 hasConcept C184235292 @default.
• W1972114211 hasConcept C185592680 @default.
• W1972114211 hasConcept C2777730290 @default.
• W1972114211 hasConcept C2778754761 @default.
• W1972114211 hasConcept C2779730028 @default.
• W1972114211 hasConcept C55493867 @default.
• W1972114211 hasConcept C62478195 @default.
• W1972114211 hasConcept C75217442 @default.
• W1972114211 hasConcept C86339819 @default.
• W1972114211 hasConcept C86554907 @default.
• W1972114211 hasConcept C86803240 @default.
• W1972114211 hasConcept C95444343 @default.
• W1972114211 hasConceptScore W1972114211C100175707 @default.
• W1972114211 hasConceptScore W1972114211C104317684 @default.
• W1972114211 hasConceptScore W1972114211C11960822 @default.
• W1972114211 hasConceptScore W1972114211C123298856 @default.
• W1972114211 hasConceptScore W1972114211C134018914 @default.
• W1972114211 hasConceptScore W1972114211C184235292 @default.
• W1972114211 hasConceptScore W1972114211C185592680 @default.
• W1972114211 hasConceptScore W1972114211C2777730290 @default.
• W1972114211 hasConceptScore W1972114211C2778754761 @default.

• next