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- W1972136836 abstract "The cis-Golgi protein GPP130 reversibly redistributes to endosomes upon pH disruption, but the identity of the endosomes and the involved cycling route are unknown. It is also unknown whether any other early Golgi proteins participate in this pathway. Here, we analyze GPP130 and the structurally related Golgi protein GP73. Unlike the TGN marker TGN38/46, GPP130 and GP73 colocalized in the early Golgi and redistributed to the ER after brefeldin A treatment. Nevertheless, after pH disruption by monensin, GPP130 and GP73 redistributed to endosomes containing redistributed TGN38/46, but not other endosomal markers. In common with TGN38/46, the redistribution involved transient appearance on the plasma membrane, and upon monensin washout, the proteins moved back to the Golgi along a microtubule- and PI3 kinase-independent route. Although GP73 did not associate with GPP130, its steady-state Golgi targeting was also mediated by a lumenal predicted coiled-coil stem domain. These findings indicate that at least two early Golgi proteins, each containing stem domain Golgi targeting determinants, cycle to the cell surface and back along the late endosome independent TGN38/46 pathway." @default.
- W1972136836 created "2016-06-24" @default.
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- W1972136836 date "2002-08-20" @default.
- W1972136836 modified "2023-10-17" @default.
- W1972136836 title "Cycling of Early Golgi Proteins Via the Cell Surface and Endosomes Upon Lumenal pH Disruption" @default.
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- W1972136836 doi "https://doi.org/10.1034/j.1600-0854.2002.30906.x" @default.
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