FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972137150> ?p ?o ?g. }

• W1972137150 endingPage "e59944" @default.
• W1972137150 startingPage "e59944" @default.
• W1972137150 abstract "The origin of cells that contribute to tendon healing, specifically extrinsic epitenon/paratenon cells vs. internal tendon fibroblasts, is still debated. The purpose of this study is to determine the location and phenotype of cells that contribute to healing of a central patellar tendon defect injury in the mouse. Normal adult patellar tendon consists of scleraxis-expressing (Scx) tendon fibroblasts situated among aligned collagen fibrils. The tendon body is surrounded by paratenon, which consists of a thin layer of cells that do not express Scx and collagen fibers oriented circumferentially around the tendon. At 3 days following injury, the paratenon thickens as cells within the paratenon proliferate and begin producing tenascin-C and fibromodulin. These cells migrate toward the defect site and express scleraxis and smooth muscle actin alpha by day 7. The thickened paratenon tissue eventually bridges the tendon defect by day 14. Similarly, cells within the periphery of the adjacent tendon struts express these markers and become disorganized. Cells within the defect region show increased expression of fibrillar collagens (Col1a1 and Col3a1) but decreased expression of tenogenic transcription factors (scleraxis and mohawk homeobox) and collagen assembly genes (fibromodulin and decorin). By contrast, early growth response 1 and 2 are upregulated in these tissues along with tenascin-C. These results suggest that paratenon cells, which normally do not express Scx, respond to injury by turning on Scx and assembling matrix to bridge the defect. Future studies are needed to determine the signaling pathways that drive these cells and whether they are capable of producing a functional tendon matrix. Understanding this process may guide tissue engineering strategies in the future by stimulating these cells to improve tendon repair." @default.
• W1972137150 created "2016-06-24" @default.
• W1972137150 creator A5006985089 @default.
• W1972137150 creator A5015323153 @default.
• W1972137150 creator A5025166480 @default.
• W1972137150 creator A5039073812 @default.
• W1972137150 creator A5047695278 @default.
• W1972137150 creator A5061550397 @default.
• W1972137150 creator A5067453135 @default.
• W1972137150 creator A5070614397 @default.
• W1972137150 creator A5081379800 @default.
• W1972137150 creator A5082728284 @default.
• W1972137150 date "2013-03-26" @default.
• W1972137150 modified "2023-10-16" @default.
• W1972137150 title "The Paratenon Contributes to Scleraxis-Expressing Cells during Patellar Tendon Healing" @default.
• W1972137150 cites W1977245294 @default.
• W1972137150 cites W1979578063 @default.
• W1972137150 cites W1981469804 @default.
• W1972137150 cites W1999851686 @default.
• W1972137150 cites W2000156083 @default.
• W1972137150 cites W2010918684 @default.
• W1972137150 cites W2012334549 @default.
• W1972137150 cites W2013079326 @default.
• W1972137150 cites W2019321312 @default.
• W1972137150 cites W2020280797 @default.
• W1972137150 cites W2032283922 @default.
• W1972137150 cites W2033653350 @default.
• W1972137150 cites W2048101828 @default.
• W1972137150 cites W2048262153 @default.
• W1972137150 cites W2048892615 @default.
• W1972137150 cites W2061223357 @default.
• W1972137150 cites W2066805444 @default.
• W1972137150 cites W2067114363 @default.
• W1972137150 cites W2080897135 @default.
• W1972137150 cites W2084484653 @default.
• W1972137150 cites W2086324555 @default.
• W1972137150 cites W2100421638 @default.
• W1972137150 cites W2107634984 @default.
• W1972137150 cites W2135466817 @default.
• W1972137150 cites W2167279371 @default.
• W1972137150 cites W2168157515 @default.
• W1972137150 doi "https://doi.org/10.1371/journal.pone.0059944" @default.
• W1972137150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3608582" @default.
• W1972137150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23555841" @default.
• W1972137150 hasPublicationYear "2013" @default.
• W1972137150 type Work @default.
• W1972137150 sameAs 1972137150 @default.
• W1972137150 citedByCount "119" @default.
• W1972137150 countsByYear W19721371502014 @default.
• W1972137150 countsByYear W19721371502015 @default.
• W1972137150 countsByYear W19721371502016 @default.
• W1972137150 countsByYear W19721371502017 @default.
• W1972137150 countsByYear W19721371502018 @default.
• W1972137150 countsByYear W19721371502019 @default.
• W1972137150 countsByYear W19721371502020 @default.
• W1972137150 countsByYear W19721371502021 @default.
• W1972137150 countsByYear W19721371502022 @default.
• W1972137150 countsByYear W19721371502023 @default.
• W1972137150 crossrefType "journal-article" @default.
• W1972137150 hasAuthorship W1972137150A5006985089 @default.
• W1972137150 hasAuthorship W1972137150A5015323153 @default.
• W1972137150 hasAuthorship W1972137150A5025166480 @default.
• W1972137150 hasAuthorship W1972137150A5039073812 @default.
• W1972137150 hasAuthorship W1972137150A5047695278 @default.
• W1972137150 hasAuthorship W1972137150A5061550397 @default.
• W1972137150 hasAuthorship W1972137150A5067453135 @default.
• W1972137150 hasAuthorship W1972137150A5070614397 @default.
• W1972137150 hasAuthorship W1972137150A5081379800 @default.
• W1972137150 hasAuthorship W1972137150A5082728284 @default.
• W1972137150 hasBestOaLocation W19721371501 @default.
• W1972137150 hasConcept C105702510 @default.
• W1972137150 hasConcept C106487976 @default.
• W1972137150 hasConcept C117961784 @default.
• W1972137150 hasConcept C185592680 @default.
• W1972137150 hasConcept C189165786 @default.
• W1972137150 hasConcept C203014093 @default.
• W1972137150 hasConcept C2779335624 @default.
• W1972137150 hasConcept C2779794767 @default.
• W1972137150 hasConcept C2780105995 @default.
• W1972137150 hasConcept C2780269544 @default.
• W1972137150 hasConcept C2780766565 @default.
• W1972137150 hasConcept C2991944018 @default.
• W1972137150 hasConcept C43617362 @default.
• W1972137150 hasConcept C86803240 @default.
• W1972137150 hasConcept C95444343 @default.
• W1972137150 hasConceptScore W1972137150C105702510 @default.
• W1972137150 hasConceptScore W1972137150C106487976 @default.
• W1972137150 hasConceptScore W1972137150C117961784 @default.
• W1972137150 hasConceptScore W1972137150C185592680 @default.
• W1972137150 hasConceptScore W1972137150C189165786 @default.
• W1972137150 hasConceptScore W1972137150C203014093 @default.
• W1972137150 hasConceptScore W1972137150C2779335624 @default.
• W1972137150 hasConceptScore W1972137150C2779794767 @default.
• W1972137150 hasConceptScore W1972137150C2780105995 @default.
• W1972137150 hasConceptScore W1972137150C2780269544 @default.
• W1972137150 hasConceptScore W1972137150C2780766565 @default.
• W1972137150 hasConceptScore W1972137150C2991944018 @default.
• W1972137150 hasConceptScore W1972137150C43617362 @default.

• next