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- W1972141862 abstract "Brain synaptosome fractions were treated by Murphy's method in order to deplete the membrane cholesterol. The binding of 35 S-chlorpromazine to these treated membranes was measured. It was found that the membrane/buffer partition coefficient of the drug was threefold greater in the treated synaptosome-rich fractions compared with the untreated fractions. The results suggest that cholesterol may not be a part of the membrane hydrophobic binding site for tranquilizers." @default.
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- W1972141862 date "1974-06-01" @default.
- W1972141862 modified "2023-09-27" @default.
- W1972141862 title "Enhanced Binding of Chlorpromazine to Cholesterol-Depleted Synaptosome Fractions" @default.
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- W1972141862 doi "https://doi.org/10.1139/y74-069" @default.
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