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• W1972142783 abstract "A genetic approach was used to investigate whether the emergence of circadian rhythms in murine pups is dependent on a functional maternal clock. Arrhythmic females bearing either the mPer1Brdm1/Per2Brdm1 or mPer2Brdm1/Cry1-/- double-mutant genotype were crossed with wild-type males under constant darkness. The heterozygous offspring have the genetic constitution for a functional circadian clock. Individual pups born to arrhythmic mPer1Brdm1/Per2Brdm1 and mPer2Brdm1/Cry1-/- mothers in constant darkness without external zeitgeber developed normal circadian rhythms, but their clocks were less synchronized to each other compared to wild-type animals. These findings indicate that development of circadian rhythms does not depend on a functional circadian clock in maternal tissue, extending previous findings obtained from pups born to SCN-lesioned mothers." @default.
• W1972142783 created "2016-06-24" @default.
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• W1972142783 date "2006-04-01" @default.
• W1972142783 modified "2023-09-25" @default.
• W1972142783 title "Circadian Rhythms in Murine Pups Develop in Absence of a Functional Maternal Circadian Clock" @default.
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• W1972142783 doi "https://doi.org/10.1177/0748730406286264" @default.
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