Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972143262> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1972143262 endingPage "407" @default.
- W1972143262 startingPage "401" @default.
- W1972143262 abstract "The purpose of this phase 2, multicentre, randomized, double-blind, placebo-controlled, 12-week dose-ranging study was to assess the efficacy, safety, and tolerability of the dipeptidyl peptidase-IV (DPP-IV) inhibitor PF-734200 in adult subjects with type 2 diabetes who were on a stable dose of metformin. Men and women with inadequate glycaemic control with metformin as their sole diabetes medication were randomized to placebo or PF-734200 2 mg, 5 mg, 10 mg, or 20 mg every day. A population subset underwent mixed meal tolerance tests (MMTT) at baseline and week 12. A total of 301 subjects were treated. At week 12, PF-734200 doses of ≥5 mg produced a statistically significant reduction in haemoglobin A1C (HbA1c) compared with placebo. The mean (95% confidence interval) placebo-adjusted changes in HbA1c were −0.31% (−0.70 to 0.08), −0.74% (−1.12 to −0.36), −0.70% (−1.02 to −0.38), and −0.75% (−1.07 to −0.43) for the 2 mg, 5 mg, 10 mg, and 20 mg doses, respectively. PF-734200 20 mg significantly reduced glucose area under the curve following MMTT (−12.8% [−22.9 to −2.7]; p=0.003) compared with placebo. The reductions observed with other doses were not statistically significant. PF-734200 was safe and well tolerated at all doses tested when added to metformin. PF-734200 safely and effectively lowered HbA1c in subjects receiving metformin. The 20 mg dose provided the greatest improvements in post-prandial glucose." @default.
- W1972143262 created "2016-06-24" @default.
- W1972143262 creator A5000786302 @default.
- W1972143262 creator A5001625709 @default.
- W1972143262 creator A5037077908 @default.
- W1972143262 creator A5039965133 @default.
- W1972143262 creator A5042888872 @default.
- W1972143262 creator A5088159366 @default.
- W1972143262 creator A5089056513 @default.
- W1972143262 creator A5090225500 @default.
- W1972143262 date "2011-04-06" @default.
- W1972143262 modified "2023-10-10" @default.
- W1972143262 title "A Dose-Ranging Study of the DPP-IV Inhibitor PF-734200 Added to Metformin in Subjects With Type 2 Diabetes" @default.
- W1972143262 doi "https://doi.org/10.1055/s-0031-1273737" @default.
- W1972143262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21472661" @default.
- W1972143262 hasPublicationYear "2011" @default.
- W1972143262 type Work @default.
- W1972143262 sameAs 1972143262 @default.
- W1972143262 citedByCount "7" @default.
- W1972143262 countsByYear W19721432622013 @default.
- W1972143262 countsByYear W19721432622014 @default.
- W1972143262 countsByYear W19721432622015 @default.
- W1972143262 countsByYear W19721432622016 @default.
- W1972143262 countsByYear W19721432622017 @default.
- W1972143262 countsByYear W19721432622019 @default.
- W1972143262 countsByYear W19721432622022 @default.
- W1972143262 countsByYear W19721432622023 @default.
- W1972143262 crossrefType "journal-article" @default.
- W1972143262 hasAuthorship W1972143262A5000786302 @default.
- W1972143262 hasAuthorship W1972143262A5001625709 @default.
- W1972143262 hasAuthorship W1972143262A5037077908 @default.
- W1972143262 hasAuthorship W1972143262A5039965133 @default.
- W1972143262 hasAuthorship W1972143262A5042888872 @default.
- W1972143262 hasAuthorship W1972143262A5088159366 @default.
- W1972143262 hasAuthorship W1972143262A5089056513 @default.
- W1972143262 hasAuthorship W1972143262A5090225500 @default.
- W1972143262 hasConcept C126322002 @default.
- W1972143262 hasConcept C134018914 @default.
- W1972143262 hasConcept C142724271 @default.
- W1972143262 hasConcept C168563851 @default.
- W1972143262 hasConcept C197934379 @default.
- W1972143262 hasConcept C204787440 @default.
- W1972143262 hasConcept C27081682 @default.
- W1972143262 hasConcept C2776312127 @default.
- W1972143262 hasConcept C2777180221 @default.
- W1972143262 hasConcept C2778375690 @default.
- W1972143262 hasConcept C2778763485 @default.
- W1972143262 hasConcept C2780323712 @default.
- W1972143262 hasConcept C2908647359 @default.
- W1972143262 hasConcept C2991744798 @default.
- W1972143262 hasConcept C44249647 @default.
- W1972143262 hasConcept C555293320 @default.
- W1972143262 hasConcept C71924100 @default.
- W1972143262 hasConcept C90924648 @default.
- W1972143262 hasConcept C99454951 @default.
- W1972143262 hasConceptScore W1972143262C126322002 @default.
- W1972143262 hasConceptScore W1972143262C134018914 @default.
- W1972143262 hasConceptScore W1972143262C142724271 @default.
- W1972143262 hasConceptScore W1972143262C168563851 @default.
- W1972143262 hasConceptScore W1972143262C197934379 @default.
- W1972143262 hasConceptScore W1972143262C204787440 @default.
- W1972143262 hasConceptScore W1972143262C27081682 @default.
- W1972143262 hasConceptScore W1972143262C2776312127 @default.
- W1972143262 hasConceptScore W1972143262C2777180221 @default.
- W1972143262 hasConceptScore W1972143262C2778375690 @default.
- W1972143262 hasConceptScore W1972143262C2778763485 @default.
- W1972143262 hasConceptScore W1972143262C2780323712 @default.
- W1972143262 hasConceptScore W1972143262C2908647359 @default.
- W1972143262 hasConceptScore W1972143262C2991744798 @default.
- W1972143262 hasConceptScore W1972143262C44249647 @default.
- W1972143262 hasConceptScore W1972143262C555293320 @default.
- W1972143262 hasConceptScore W1972143262C71924100 @default.
- W1972143262 hasConceptScore W1972143262C90924648 @default.
- W1972143262 hasConceptScore W1972143262C99454951 @default.
- W1972143262 hasIssue "07" @default.
- W1972143262 hasLocation W19721432621 @default.
- W1972143262 hasLocation W19721432622 @default.
- W1972143262 hasOpenAccess W1972143262 @default.
- W1972143262 hasPrimaryLocation W19721432621 @default.
- W1972143262 hasRelatedWork W1532760157 @default.
- W1972143262 hasRelatedWork W1972143262 @default.
- W1972143262 hasRelatedWork W1991565451 @default.
- W1972143262 hasRelatedWork W2005084305 @default.
- W1972143262 hasRelatedWork W2016264464 @default.
- W1972143262 hasRelatedWork W2025436379 @default.
- W1972143262 hasRelatedWork W2031540476 @default.
- W1972143262 hasRelatedWork W2033313326 @default.
- W1972143262 hasRelatedWork W2744240433 @default.
- W1972143262 hasRelatedWork W3114127255 @default.
- W1972143262 hasVolume "119" @default.
- W1972143262 isParatext "false" @default.
- W1972143262 isRetracted "false" @default.
- W1972143262 magId "1972143262" @default.
- W1972143262 workType "article" @default.