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- W1972148870 abstract "Heterotrimeric G proteins are well known for their function in signal transduction downstream of seven transmembrane receptors. More recently, however, genetic analysis in C. elegans and in Drosophila has revealed a second, essential function of these molecules in positioning the mitotic spindle and attaching microtubules to the cell cortex. Five new publications in Cell (Afshar et al., 2004; Du and Macara, 2004 [this issue of Cell]; Hess et al. 2004Hess H.A. Roeper J.C. Grill S. Koelle M. Cell. 2004; 119: 209-218Abstract Full Text Full Text PDF PubMed Scopus (83) Google Scholar), Developmental Cell (Martin-McCaffrey et al. 2004Martin-McCaffrey L. Willard F.S. Oliveira-dos-Santos A.J. Natale D.R.C. Snow B.E. Kimple R.J. Pajak A. Watson A.J. Dagnino L. Penninger J.M. et al.Dev. Cell. 2004; 7: 763-769Abstract Full Text Full Text PDF PubMed Scopus (50) Google Scholar), and Current Biology (Couwenbergs et al. 2004Couwenbergs C. Spilker A.C. Gotta M. Curr. Biol. 2004; 14: 1871-1876Abstract Full Text Full Text PDF PubMed Scopus (79) Google Scholar) show that this function is conserved in vertebrates and—like the classical pathway—involves cycling of G proteins between GDP and GTP bound conformations." @default.
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- W1972148870 title "Heterotrimeric G Proteins" @default.
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- W1972148870 doi "https://doi.org/10.1016/j.cell.2004.10.025" @default.
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