FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972155103> ?p ?o ?g. }

• W1972155103 endingPage "110" @default.
• W1972155103 startingPage "103" @default.
• W1972155103 abstract "Thymidine phosphorylase (TP) regulates intracellular thymidine metabolism. It has been reported to be a prognostic factor for tumor angiogenesis and to activate some prodrugs of 5-fluorouracil (5-FU) to 5-FU. There is also evidence that TP is induced by interferons (IFNs) and xenobiotics, such as cyclophosphamide and taxanes, in experimental human cancer cells and xenografts. We investigated the induction of TP expression by IFNalpha and Paclitaxel in vitro and in vivo in human tumor cells with low and with high TP activity. TP activity in KB, NUGC-3, and KOC2S cells, which had low TP activity, was increased 2 to 4 fold by IFNalpha, but was still lower than in non-treated SHIN-3 and HRA cells, which have high TP activity. IFNalpha did not promote TP activity in SHIN-3 and HRA cells, but expression of TP mRNA increased 2 to 4 fold in response to IFNalpha in all cells tested. These results suggest that the expression of TP protein would be regulated post-transcriptionally by another factor after IFN-induced amplification of TP mRNA. A single dose of Paclitaxel to nude mice xenografted with KB and KM20C tumors, expressing low TP activity, increased TP activity about 4 to 7 fold compared to non-treated tumors. In contrast, TP expression in MX-1 and H-31 tumors was originally high and did not change by the treatment of Paclitaxel. The activities of uridine phosphorylase in all tumors used showed no changes in response to IFNalpha or Paclitaxel. We determined the level of STAT1alpha, an IFN-inducible transcription factor of the TP gene, and found that it was low in low TP expressing tumor cells and markedly increased to about 4 fold by IFN, almost reaching the level in high TP expressing cells whose STAT1alpha level was unchanged by IFN. When TP activity and STAT1alpha expression in clinically resected colorectal cancers were simultaneously measured, almost all tumors had high expression of both TP and STAT1alpha. In conclusion, our results suggest that IFN and Paclitaxel affect human cancer cells with low TP activity but not those with high TP activity and that the STAT1alpha expression may reflect TP activity, at least in experimental human cancer cells." @default.
• W1972155103 created "2016-06-24" @default.
• W1972155103 creator A5008014743 @default.
• W1972155103 creator A5029970515 @default.
• W1972155103 creator A5047958905 @default.
• W1972155103 creator A5058238996 @default.
• W1972155103 creator A5073764534 @default.
• W1972155103 date "2002-12-01" @default.
• W1972155103 modified "2023-09-26" @default.
• W1972155103 title "Induction of thymidine phosphorylase by interferon and taxanes occurs only in human cancer cells with low thymidine phosphorylase activity" @default.
• W1972155103 cites W1530403388 @default.
• W1972155103 cites W1537854451 @default.
• W1972155103 cites W1972770199 @default.
• W1972155103 cites W1978347107 @default.
• W1972155103 cites W1980850901 @default.
• W1972155103 cites W1986625462 @default.
• W1972155103 cites W1989159654 @default.
• W1972155103 cites W2038563885 @default.
• W1972155103 cites W2047643960 @default.
• W1972155103 cites W2064200336 @default.
• W1972155103 cites W2094810573 @default.
• W1972155103 cites W2095181507 @default.
• W1972155103 cites W2097906802 @default.
• W1972155103 cites W2118577784 @default.
• W1972155103 cites W2162907832 @default.
• W1972155103 cites W2329104811 @default.
• W1972155103 doi "https://doi.org/10.1016/s0304-3835(02)00358-0" @default.
• W1972155103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12359357" @default.
• W1972155103 hasPublicationYear "2002" @default.
• W1972155103 type Work @default.
• W1972155103 sameAs 1972155103 @default.
• W1972155103 citedByCount "24" @default.
• W1972155103 countsByYear W19721551032012 @default.
• W1972155103 countsByYear W19721551032013 @default.
• W1972155103 countsByYear W19721551032015 @default.
• W1972155103 countsByYear W19721551032016 @default.
• W1972155103 crossrefType "journal-article" @default.
• W1972155103 hasAuthorship W1972155103A5008014743 @default.
• W1972155103 hasAuthorship W1972155103A5029970515 @default.
• W1972155103 hasAuthorship W1972155103A5047958905 @default.
• W1972155103 hasAuthorship W1972155103A5058238996 @default.
• W1972155103 hasAuthorship W1972155103A5073764534 @default.
• W1972155103 hasConcept C121608353 @default.
• W1972155103 hasConcept C126322002 @default.
• W1972155103 hasConcept C134018914 @default.
• W1972155103 hasConcept C150903083 @default.
• W1972155103 hasConcept C185592680 @default.
• W1972155103 hasConcept C202751555 @default.
• W1972155103 hasConcept C207001950 @default.
• W1972155103 hasConcept C2776735402 @default.
• W1972155103 hasConcept C2777108182 @default.
• W1972155103 hasConcept C2777292972 @default.
• W1972155103 hasConcept C2780394083 @default.
• W1972155103 hasConcept C502942594 @default.
• W1972155103 hasConcept C55493867 @default.
• W1972155103 hasConcept C71924100 @default.
• W1972155103 hasConcept C86803240 @default.
• W1972155103 hasConcept C96232424 @default.
• W1972155103 hasConceptScore W1972155103C121608353 @default.
• W1972155103 hasConceptScore W1972155103C126322002 @default.
• W1972155103 hasConceptScore W1972155103C134018914 @default.
• W1972155103 hasConceptScore W1972155103C150903083 @default.
• W1972155103 hasConceptScore W1972155103C185592680 @default.
• W1972155103 hasConceptScore W1972155103C202751555 @default.
• W1972155103 hasConceptScore W1972155103C207001950 @default.
• W1972155103 hasConceptScore W1972155103C2776735402 @default.
• W1972155103 hasConceptScore W1972155103C2777108182 @default.
• W1972155103 hasConceptScore W1972155103C2777292972 @default.
• W1972155103 hasConceptScore W1972155103C2780394083 @default.
• W1972155103 hasConceptScore W1972155103C502942594 @default.
• W1972155103 hasConceptScore W1972155103C55493867 @default.
• W1972155103 hasConceptScore W1972155103C71924100 @default.
• W1972155103 hasConceptScore W1972155103C86803240 @default.
• W1972155103 hasConceptScore W1972155103C96232424 @default.
• W1972155103 hasIssue "1-2" @default.
• W1972155103 hasLocation W19721551031 @default.
• W1972155103 hasLocation W19721551032 @default.
• W1972155103 hasOpenAccess W1972155103 @default.
• W1972155103 hasPrimaryLocation W19721551031 @default.
• W1972155103 hasRelatedWork W1980030999 @default.
• W1972155103 hasRelatedWork W1989943708 @default.
• W1972155103 hasRelatedWork W2022678399 @default.
• W1972155103 hasRelatedWork W2028250415 @default.
• W1972155103 hasRelatedWork W2045148207 @default.
• W1972155103 hasRelatedWork W2048682946 @default.
• W1972155103 hasRelatedWork W2354125101 @default.
• W1972155103 hasRelatedWork W2368257851 @default.
• W1972155103 hasRelatedWork W4248568275 @default.
• W1972155103 hasRelatedWork W4283771460 @default.
• W1972155103 hasVolume "187" @default.
• W1972155103 isParatext "false" @default.
• W1972155103 isRetracted "false" @default.
• W1972155103 magId "1972155103" @default.
• W1972155103 workType "article" @default.