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- W1972157058 abstract "In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE." @default.
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- W1972157058 date "2013-12-01" @default.
- W1972157058 modified "2023-10-06" @default.
- W1972157058 title "Leptin promotes lupus T-cell autoimmunity" @default.
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- W1972157058 doi "https://doi.org/10.1016/j.clim.2013.09.002" @default.
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