Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972166807> ?p ?o ?g. }
- W1972166807 endingPage "170" @default.
- W1972166807 startingPage "162" @default.
- W1972166807 abstract "Aging is a major risk factor for osteoarthritis (OA). Forkhead-box class O (FoxO) transcription factors regulate mechanisms of cellular aging, including protein quality control, autophagy and defenses against oxidative stress. The objective of this study was to analyze FoxO transcription factors in normal, aging and OA cartilage.Knee joints from humans ages 23-90 and from mice at the age of 4-24 months and following surgically induced OA were analyzed for expression of FoxO proteins. Regulation of FoxO protein expression and activation was analyzed in cultured chondrocytes.Human cartilage expressed FOXO1 and FOXO3 but not FOXO4 proteins. FOXO1 and FOXO3 were more strongly expressed the superficial and mid zone as compared to the deep zone and were mainly localized in nuclei. During human joint aging, expression of FOXO1 and FOXO3 was markedly reduced in the superficial zone of cartilage regions exposed to maximal weight bearing. In OA cartilage, chondrocyte clusters showed strong FOXO phosphorylation and cytoplasmic localization. Similar patterns of FOXO expression in normal joints and changes in aging and OA were observed in mouse models. In cultured chondrocytes, IL-1β and TNF-α suppressed FOXO1, while TGF-β and PDGF increased FOXO1 and FOXO3 expression. FOXO1 and FOXO3 phosphorylation was increased by IL-1β, PDGF, bFGF, IGF-1, and the oxidant t-BHP.Normal articular cartilage has a tissue specific signature of FoxO expression and activation and this is profoundly altered in aging and OA in humans and mice. Changes in FoxO expression and activation may be involved in cartilage aging and OA." @default.
- W1972166807 created "2016-06-24" @default.
- W1972166807 creator A5011966088 @default.
- W1972166807 creator A5049188247 @default.
- W1972166807 creator A5065427229 @default.
- W1972166807 creator A5079153267 @default.
- W1972166807 creator A5080699797 @default.
- W1972166807 creator A5087156611 @default.
- W1972166807 date "2014-01-01" @default.
- W1972166807 modified "2023-10-16" @default.
- W1972166807 title "Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis" @default.
- W1972166807 cites W1812173421 @default.
- W1972166807 cites W1964710354 @default.
- W1972166807 cites W1965671005 @default.
- W1972166807 cites W1974178287 @default.
- W1972166807 cites W1978098619 @default.
- W1972166807 cites W1979147887 @default.
- W1972166807 cites W1979225796 @default.
- W1972166807 cites W1982453959 @default.
- W1972166807 cites W1985004392 @default.
- W1972166807 cites W1994541481 @default.
- W1972166807 cites W2001605681 @default.
- W1972166807 cites W2014140858 @default.
- W1972166807 cites W2015351957 @default.
- W1972166807 cites W2023623228 @default.
- W1972166807 cites W2029769474 @default.
- W1972166807 cites W2045554095 @default.
- W1972166807 cites W2046623154 @default.
- W1972166807 cites W2053108974 @default.
- W1972166807 cites W2063826393 @default.
- W1972166807 cites W2069306070 @default.
- W1972166807 cites W2070350980 @default.
- W1972166807 cites W2071491944 @default.
- W1972166807 cites W2075427507 @default.
- W1972166807 cites W2076124709 @default.
- W1972166807 cites W2082852887 @default.
- W1972166807 cites W2083416570 @default.
- W1972166807 cites W2085299577 @default.
- W1972166807 cites W2087168227 @default.
- W1972166807 cites W2092746514 @default.
- W1972166807 cites W2096648574 @default.
- W1972166807 cites W2099364141 @default.
- W1972166807 cites W2099952840 @default.
- W1972166807 cites W2108888253 @default.
- W1972166807 cites W2109697658 @default.
- W1972166807 cites W2114263381 @default.
- W1972166807 cites W2127382439 @default.
- W1972166807 cites W2128677681 @default.
- W1972166807 cites W2133711376 @default.
- W1972166807 cites W2137742454 @default.
- W1972166807 cites W2155936356 @default.
- W1972166807 cites W2162857699 @default.
- W1972166807 cites W4292542165 @default.
- W1972166807 doi "https://doi.org/10.1016/j.joca.2013.11.004" @default.
- W1972166807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3932989" @default.
- W1972166807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24269635" @default.
- W1972166807 hasPublicationYear "2014" @default.
- W1972166807 type Work @default.
- W1972166807 sameAs 1972166807 @default.
- W1972166807 citedByCount "112" @default.
- W1972166807 countsByYear W19721668072014 @default.
- W1972166807 countsByYear W19721668072015 @default.
- W1972166807 countsByYear W19721668072016 @default.
- W1972166807 countsByYear W19721668072017 @default.
- W1972166807 countsByYear W19721668072018 @default.
- W1972166807 countsByYear W19721668072019 @default.
- W1972166807 countsByYear W19721668072020 @default.
- W1972166807 countsByYear W19721668072021 @default.
- W1972166807 countsByYear W19721668072022 @default.
- W1972166807 countsByYear W19721668072023 @default.
- W1972166807 crossrefType "journal-article" @default.
- W1972166807 hasAuthorship W1972166807A5011966088 @default.
- W1972166807 hasAuthorship W1972166807A5049188247 @default.
- W1972166807 hasAuthorship W1972166807A5065427229 @default.
- W1972166807 hasAuthorship W1972166807A5079153267 @default.
- W1972166807 hasAuthorship W1972166807A5080699797 @default.
- W1972166807 hasAuthorship W1972166807A5087156611 @default.
- W1972166807 hasBestOaLocation W19721668071 @default.
- W1972166807 hasConcept C104317684 @default.
- W1972166807 hasConcept C105702510 @default.
- W1972166807 hasConcept C11960822 @default.
- W1972166807 hasConcept C126322002 @default.
- W1972166807 hasConcept C134018914 @default.
- W1972166807 hasConcept C140149449 @default.
- W1972166807 hasConcept C142724271 @default.
- W1972166807 hasConcept C168003608 @default.
- W1972166807 hasConcept C185592680 @default.
- W1972166807 hasConcept C204787440 @default.
- W1972166807 hasConcept C2776164576 @default.
- W1972166807 hasConcept C2780550940 @default.
- W1972166807 hasConcept C2781403057 @default.
- W1972166807 hasConcept C522857546 @default.
- W1972166807 hasConcept C55493867 @default.
- W1972166807 hasConcept C71924100 @default.
- W1972166807 hasConcept C75217442 @default.
- W1972166807 hasConcept C86339819 @default.
- W1972166807 hasConcept C86803240 @default.
- W1972166807 hasConcept C95444343 @default.