Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972168906> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1972168906 endingPage "97" @default.
- W1972168906 startingPage "90" @default.
- W1972168906 abstract "The current randomized, multicenter, Phase III trial was conducted to determine whether the disease free interval and overall survival of patients with T2-T4,N0-N3,M0 squamous cell carcinoma (SCC) of the oral cavity or oropharynx could be extended through the combination of surgery (and radiotherapy, if required) with perilymphatic recombinant IL-2 (rIL-2).Patients with a resectable T2-T4,N0-N3,M0 SCC of the oral cavity and oropharynx were assigned randomly to receive surgery and radiotherapy or to receive IL-2, surgery, and radiotherapy. Five thousand units of rIL-2 were injected around the ipsilateral cervical lymph node chain daily for 10 days before surgery. After surgery, contralateral 5-day rIL-2 courses were administered monthly for 1 year. The differences in disease free and overall survival between the two groups of patients were evaluated statistically.Two hundred two patients finished the study. No significant complications related to rIL-2 were encountered, and surgery and radiotherapy were not hampered by its prior administration. Multivariate analysis conducted to determine the extent to which survival was influenced by rIL-2 and the other variables showed that rIL-2 significantly lengthened disease free survival (P < 0.01) and that this resulted in longer overall survival (P < 0.03).The data emerging from this trial indicate that perilymphatic administration of low, nontoxic doses of rIL-2 is a simple and manageable way to delay recurrences of SCC." @default.
- W1972168906 created "2016-06-24" @default.
- W1972168906 creator A5015187471 @default.
- W1972168906 creator A5032250523 @default.
- W1972168906 creator A5040194068 @default.
- W1972168906 creator A5044272723 @default.
- W1972168906 creator A5056252885 @default.
- W1972168906 creator A5061193350 @default.
- W1972168906 creator A5069493835 @default.
- W1972168906 creator A5075800174 @default.
- W1972168906 date "2002-06-28" @default.
- W1972168906 modified "2023-10-10" @default.
- W1972168906 title "Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx" @default.
- W1972168906 cites W1980857927 @default.
- W1972168906 cites W1981787863 @default.
- W1972168906 cites W2007343138 @default.
- W1972168906 cites W2023411546 @default.
- W1972168906 cites W2048331497 @default.
- W1972168906 cites W2048421920 @default.
- W1972168906 cites W2053670125 @default.
- W1972168906 cites W2108221597 @default.
- W1972168906 cites W213080353 @default.
- W1972168906 doi "https://doi.org/10.1002/cncr.10654" @default.
- W1972168906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12115321" @default.
- W1972168906 hasPublicationYear "2002" @default.
- W1972168906 type Work @default.
- W1972168906 sameAs 1972168906 @default.
- W1972168906 citedByCount "58" @default.
- W1972168906 countsByYear W19721689062012 @default.
- W1972168906 countsByYear W19721689062013 @default.
- W1972168906 countsByYear W19721689062015 @default.
- W1972168906 countsByYear W19721689062016 @default.
- W1972168906 countsByYear W19721689062017 @default.
- W1972168906 countsByYear W19721689062018 @default.
- W1972168906 countsByYear W19721689062019 @default.
- W1972168906 countsByYear W19721689062020 @default.
- W1972168906 countsByYear W19721689062021 @default.
- W1972168906 countsByYear W19721689062022 @default.
- W1972168906 crossrefType "journal-article" @default.
- W1972168906 hasAuthorship W1972168906A5015187471 @default.
- W1972168906 hasAuthorship W1972168906A5032250523 @default.
- W1972168906 hasAuthorship W1972168906A5040194068 @default.
- W1972168906 hasAuthorship W1972168906A5044272723 @default.
- W1972168906 hasAuthorship W1972168906A5056252885 @default.
- W1972168906 hasAuthorship W1972168906A5061193350 @default.
- W1972168906 hasAuthorship W1972168906A5069493835 @default.
- W1972168906 hasAuthorship W1972168906A5075800174 @default.
- W1972168906 hasConcept C10515644 @default.
- W1972168906 hasConcept C126322002 @default.
- W1972168906 hasConcept C141071460 @default.
- W1972168906 hasConcept C168563851 @default.
- W1972168906 hasConcept C2777546739 @default.
- W1972168906 hasConcept C2780849966 @default.
- W1972168906 hasConcept C3019992690 @default.
- W1972168906 hasConcept C509974204 @default.
- W1972168906 hasConcept C71924100 @default.
- W1972168906 hasConceptScore W1972168906C10515644 @default.
- W1972168906 hasConceptScore W1972168906C126322002 @default.
- W1972168906 hasConceptScore W1972168906C141071460 @default.
- W1972168906 hasConceptScore W1972168906C168563851 @default.
- W1972168906 hasConceptScore W1972168906C2777546739 @default.
- W1972168906 hasConceptScore W1972168906C2780849966 @default.
- W1972168906 hasConceptScore W1972168906C3019992690 @default.
- W1972168906 hasConceptScore W1972168906C509974204 @default.
- W1972168906 hasConceptScore W1972168906C71924100 @default.
- W1972168906 hasIssue "1" @default.
- W1972168906 hasLocation W19721689061 @default.
- W1972168906 hasLocation W19721689062 @default.
- W1972168906 hasOpenAccess W1972168906 @default.
- W1972168906 hasPrimaryLocation W19721689061 @default.
- W1972168906 hasRelatedWork W177678164 @default.
- W1972168906 hasRelatedWork W2056534599 @default.
- W1972168906 hasRelatedWork W2066639416 @default.
- W1972168906 hasRelatedWork W2355955825 @default.
- W1972168906 hasRelatedWork W2359001965 @default.
- W1972168906 hasRelatedWork W2382476776 @default.
- W1972168906 hasRelatedWork W2383628288 @default.
- W1972168906 hasRelatedWork W3032375220 @default.
- W1972168906 hasRelatedWork W3210497498 @default.
- W1972168906 hasRelatedWork W4386267927 @default.
- W1972168906 hasVolume "95" @default.
- W1972168906 isParatext "false" @default.
- W1972168906 isRetracted "false" @default.
- W1972168906 magId "1972168906" @default.
- W1972168906 workType "article" @default.