FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972178925> ?p ?o ?g. }

• W1972178925 endingPage "694" @default.
• W1972178925 startingPage "684" @default.
• W1972178925 abstract "The PI3K-PKB pathway is an important and widely studied pathway in cell signaling. The enzyme activity of PI3K produces D-3 phosphoinositides, including the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. PI(3,4,5)P3 has been deemed to be the most important second messenger for triggering PKB phosphorylation. PKB has two regulatory phosphorylation sites, Thr308 and Ser473, both of which contribute to its full activity. The direct relationship between PI3K lipid products and PKB phosphorylation is still not entirely clear. Our previous study showed that PI(3,4)P2 has a specific role in contributing to PKB phosphorylation on Ser473 sites in mast cells. In this study, we used two strategies to further elucidate this question in a well-established B cell system. First, by SHIP overexpression, we examined PKB activation under conditions where PI(3,4,5)P3 accumulation is largely suppressed. Second, we used dose response of different forms of B-cell receptor ligands to manipulate the relative levels of PI(3,4,5)P3 and PI(3,4)P2. Our results demonstrate a close relationship between PI(3,4,5)P3 levels and Thr308 phosphorylation levels, and PI(3,4)P2 levels and Ser473 phosphorylation levels, respectively. Furthermore, overall PKB activity, primarily consisting of cytosolic enzyme, was dependent upon levels of PI(3,4)P2, while only membrane-associated PKB activity was dependent upon PI(3,4,5)P3 levels. We conclude that PI(3,4,5)P3 and PI(3,4)P2 have distinct roles in determining PKB phosphorylation and activity. Thus, when investigating PI3K-PKB pathways, the importance of both lipids must be considered." @default.
• W1972178925 created "2016-06-24" @default.
• W1972178925 creator A5015319915 @default.
• W1972178925 creator A5024170653 @default.
• W1972178925 creator A5050668557 @default.
• W1972178925 creator A5062983293 @default.
• W1972178925 date "2008-04-01" @default.
• W1972178925 modified "2023-10-17" @default.
• W1972178925 title "PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity" @default.
• W1972178925 cites W1557923725 @default.
• W1972178925 cites W1566581202 @default.
• W1972178925 cites W1592624601 @default.
• W1972178925 cites W1675574531 @default.
• W1972178925 cites W1861660397 @default.
• W1972178925 cites W1963825704 @default.
• W1972178925 cites W1965616500 @default.
• W1972178925 cites W1969134590 @default.
• W1972178925 cites W1987218173 @default.
• W1972178925 cites W2005131087 @default.
• W1972178925 cites W2010736123 @default.
• W1972178925 cites W2010784970 @default.
• W1972178925 cites W2020544348 @default.
• W1972178925 cites W2026145775 @default.
• W1972178925 cites W2044005459 @default.
• W1972178925 cites W2056462157 @default.
• W1972178925 cites W2064242629 @default.
• W1972178925 cites W2065989299 @default.
• W1972178925 cites W2068455515 @default.
• W1972178925 cites W2069545269 @default.
• W1972178925 cites W2078685722 @default.
• W1972178925 cites W2094068658 @default.
• W1972178925 cites W2095304369 @default.
• W1972178925 cites W2103421087 @default.
• W1972178925 cites W2111202304 @default.
• W1972178925 cites W2126404692 @default.
• W1972178925 cites W2133496311 @default.
• W1972178925 cites W2134295150 @default.
• W1972178925 cites W2146157811 @default.
• W1972178925 cites W2148144033 @default.
• W1972178925 cites W2149334947 @default.
• W1972178925 cites W2153404441 @default.
• W1972178925 cites W2160922815 @default.
• W1972178925 cites W2165742826 @default.
• W1972178925 cites W2431345963 @default.
• W1972178925 cites W4234842415 @default.
• W1972178925 cites W4241058123 @default.
• W1972178925 doi "https://doi.org/10.1016/j.cellsig.2007.12.004" @default.
• W1972178925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18249092" @default.
• W1972178925 hasPublicationYear "2008" @default.
• W1972178925 type Work @default.
• W1972178925 sameAs 1972178925 @default.
• W1972178925 citedByCount "113" @default.
• W1972178925 countsByYear W19721789252012 @default.
• W1972178925 countsByYear W19721789252013 @default.
• W1972178925 countsByYear W19721789252014 @default.
• W1972178925 countsByYear W19721789252015 @default.
• W1972178925 countsByYear W19721789252016 @default.
• W1972178925 countsByYear W19721789252017 @default.
• W1972178925 countsByYear W19721789252018 @default.
• W1972178925 countsByYear W19721789252019 @default.
• W1972178925 countsByYear W19721789252020 @default.
• W1972178925 countsByYear W19721789252021 @default.
• W1972178925 countsByYear W19721789252022 @default.
• W1972178925 countsByYear W19721789252023 @default.
• W1972178925 crossrefType "journal-article" @default.
• W1972178925 hasAuthorship W1972178925A5015319915 @default.
• W1972178925 hasAuthorship W1972178925A5024170653 @default.
• W1972178925 hasAuthorship W1972178925A5050668557 @default.
• W1972178925 hasAuthorship W1972178925A5062983293 @default.
• W1972178925 hasConcept C11960822 @default.
• W1972178925 hasConcept C163235415 @default.
• W1972178925 hasConcept C181199279 @default.
• W1972178925 hasConcept C185592680 @default.
• W1972178925 hasConcept C53009064 @default.
• W1972178925 hasConcept C55493867 @default.
• W1972178925 hasConcept C62478195 @default.
• W1972178925 hasConcept C75217442 @default.
• W1972178925 hasConcept C86554907 @default.
• W1972178925 hasConcept C86803240 @default.
• W1972178925 hasConcept C95444343 @default.
• W1972178925 hasConcept C98539663 @default.
• W1972178925 hasConceptScore W1972178925C11960822 @default.
• W1972178925 hasConceptScore W1972178925C163235415 @default.
• W1972178925 hasConceptScore W1972178925C181199279 @default.
• W1972178925 hasConceptScore W1972178925C185592680 @default.
• W1972178925 hasConceptScore W1972178925C53009064 @default.
• W1972178925 hasConceptScore W1972178925C55493867 @default.
• W1972178925 hasConceptScore W1972178925C62478195 @default.
• W1972178925 hasConceptScore W1972178925C75217442 @default.
• W1972178925 hasConceptScore W1972178925C86554907 @default.
• W1972178925 hasConceptScore W1972178925C86803240 @default.
• W1972178925 hasConceptScore W1972178925C95444343 @default.
• W1972178925 hasConceptScore W1972178925C98539663 @default.
• W1972178925 hasIssue "4" @default.
• W1972178925 hasLocation W19721789251 @default.
• W1972178925 hasLocation W19721789252 @default.
• W1972178925 hasOpenAccess W1972178925 @default.
• W1972178925 hasPrimaryLocation W19721789251 @default.

• next