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• W1972193702 abstract "<h2>Abstract</h2> The mechanisms leading to left ventricular (LV) asynchronies are incompletely understood, and reports on the functional significance of asynchronies for the affected segments are conflicting. To characterize LV asynchronies, 16 anesthetized docs with critical stenosis of the left anterior descending coronary artery (LAD) were instrumented to measure sub-endocardial contractile function (sonomicrometry) and the ECG in the LAD territory. The subendocardial ECG was also recorded from the anterior basal LV territory. Time of regional S wave arrival (TS) and time of onset of segment shortening were determined. The animals underwent atrial pacing with increasing frequencies until systolic LAD territory contractile dysfunction and eventual LV asynchronies were observed. Six animals without LAD stenosis served as controls to define the normal response (mean ± 2 · SD) to increasing pacing rates of systolic shortening and onset time of segment shortening (time difference between TS and onset of segment shortening). LAD contractile dysfunction was considered as a systolic shortening below the normal range, and LV asynchronies as an onset time of segment shortening above the normal range. When LV asynchronies occurred, onset time of segment shortening in the LAD territory was 80.1 ± 4.9 ms versus 14.8 ± 3.7 ms at control (<i>P</i> < 0.01); the time difference between S wave arrival in the LAD and circumflex territories, however, was unchanged. LV asynchronies were associated with marked LAD territory contractile dysfunction (systolic shortening of 9.6 ± 0.8% <i>v</i> 21.0 ± 1.9% at control, after systolic shortening of 31.3 3.8% <i>v</i> 9.0 ± 2.6% at control; <i>P</i> < 0.01). In conclusion, LV asynchronies occurring during pacing tachycardia are induced by a dramatic delay in onset of segment shortening due to a marked increase in onset time of segment shortening and are associated with marked contractile dysfunction in the affected segment. Regionally delayed arrival of electrical activation can be excluded as a mechanism leading to LV asynchronies." @default.
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• W1972193702 date "1993-12-01" @default.
• W1972193702 modified "2023-10-18" @default.
• W1972193702 title "Pacing-induced left ventricular asynchronies in dogs with critical coronary stenosis: Mechanisms and effect of anesthetics" @default.
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• W1972193702 doi "https://doi.org/10.1016/1053-0770(93)90055-p" @default.
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