Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972199034> ?p ?o ?g. }
- W1972199034 endingPage "1165" @default.
- W1972199034 startingPage "1158" @default.
- W1972199034 abstract "Despite previous studies suggesting that surgery cause immune suppression, the underlying biologic mechanisms have not been studied using advanced immune function assays. Unilateral nephrectomy was performed in nonhuman primates. Blood was collected before surgery and at different time-points through 14 days after surgery. Lymphocyte proliferation (expression of proliferating cell nuclear antigen in cells in S/G(2)M-phase), production of intracellular cytokines [interleukin (IL)-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha] and expression of surface-activation antigens (CD25, CD71) on T-lymphocytes were assessed in whole blood using flow cytometry. Results were compared with nonoperated control animals. The procedure caused a decrease of 25% in absolute lymphocyte count on postoperative day 3. Inhibition of lymphocyte proliferation was maximal on postoperative day 1 (55% normalized to preoperative values) and was detectable until postoperative day 7, when it was 25%. Expression of T-cell activation antigens was decreased during the first postoperative week with a maximum on postoperative day 1 for CD71 (29%) and on postoperative day 3 for CD25 (49%). Intracellular production of cytokines by T cells was decreased only on postoperative day 1 (50% for IL-2, 29% for IFN-gamma and 22% for TNF-alpha). Immune functions returned to presurgery values by day 14. A major surgical procedure severely inhibits lymphocyte proliferation and various T-cell functions up to 1 week postoperatively." @default.
- W1972199034 created "2016-06-24" @default.
- W1972199034 creator A5019023881 @default.
- W1972199034 creator A5033796818 @default.
- W1972199034 creator A5049232814 @default.
- W1972199034 creator A5079989008 @default.
- W1972199034 creator A5088941214 @default.
- W1972199034 date "2005-10-01" @default.
- W1972199034 modified "2023-10-02" @default.
- W1972199034 title "Immunosuppressive effects of surgery assessed by flow cytometry in nonhuman primates after nephrectomy" @default.
- W1972199034 cites W1607180257 @default.
- W1972199034 cites W1964241765 @default.
- W1972199034 cites W1986395580 @default.
- W1972199034 cites W1988279083 @default.
- W1972199034 cites W1990511826 @default.
- W1972199034 cites W1990923666 @default.
- W1972199034 cites W1996997726 @default.
- W1972199034 cites W1997540630 @default.
- W1972199034 cites W2009659738 @default.
- W1972199034 cites W2022142782 @default.
- W1972199034 cites W2024766718 @default.
- W1972199034 cites W2026108503 @default.
- W1972199034 cites W2029962574 @default.
- W1972199034 cites W2037103655 @default.
- W1972199034 cites W2039470219 @default.
- W1972199034 cites W2048513472 @default.
- W1972199034 cites W2048953132 @default.
- W1972199034 cites W2050835978 @default.
- W1972199034 cites W2051998790 @default.
- W1972199034 cites W2061986702 @default.
- W1972199034 cites W2062200593 @default.
- W1972199034 cites W2062591290 @default.
- W1972199034 cites W2070659456 @default.
- W1972199034 cites W2077989877 @default.
- W1972199034 cites W2090885361 @default.
- W1972199034 cites W2139229312 @default.
- W1972199034 cites W2142494698 @default.
- W1972199034 cites W2150674484 @default.
- W1972199034 cites W2152054410 @default.
- W1972199034 cites W2154121987 @default.
- W1972199034 cites W2158981591 @default.
- W1972199034 doi "https://doi.org/10.1111/j.1432-2277.2005.00119.x" @default.
- W1972199034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16162103" @default.
- W1972199034 hasPublicationYear "2005" @default.
- W1972199034 type Work @default.
- W1972199034 sameAs 1972199034 @default.
- W1972199034 citedByCount "12" @default.
- W1972199034 countsByYear W19721990342012 @default.
- W1972199034 countsByYear W19721990342013 @default.
- W1972199034 countsByYear W19721990342014 @default.
- W1972199034 countsByYear W19721990342017 @default.
- W1972199034 countsByYear W19721990342018 @default.
- W1972199034 countsByYear W19721990342019 @default.
- W1972199034 countsByYear W19721990342020 @default.
- W1972199034 crossrefType "journal-article" @default.
- W1972199034 hasAuthorship W1972199034A5019023881 @default.
- W1972199034 hasAuthorship W1972199034A5033796818 @default.
- W1972199034 hasAuthorship W1972199034A5049232814 @default.
- W1972199034 hasAuthorship W1972199034A5079989008 @default.
- W1972199034 hasAuthorship W1972199034A5088941214 @default.
- W1972199034 hasConcept C126322002 @default.
- W1972199034 hasConcept C147483822 @default.
- W1972199034 hasConcept C16685009 @default.
- W1972199034 hasConcept C203014093 @default.
- W1972199034 hasConcept C2776090121 @default.
- W1972199034 hasConcept C2777371288 @default.
- W1972199034 hasConcept C2777761686 @default.
- W1972199034 hasConcept C2780091579 @default.
- W1972199034 hasConcept C2780227381 @default.
- W1972199034 hasConcept C553184892 @default.
- W1972199034 hasConcept C71924100 @default.
- W1972199034 hasConcept C79484868 @default.
- W1972199034 hasConcept C8891405 @default.
- W1972199034 hasConceptScore W1972199034C126322002 @default.
- W1972199034 hasConceptScore W1972199034C147483822 @default.
- W1972199034 hasConceptScore W1972199034C16685009 @default.
- W1972199034 hasConceptScore W1972199034C203014093 @default.
- W1972199034 hasConceptScore W1972199034C2776090121 @default.
- W1972199034 hasConceptScore W1972199034C2777371288 @default.
- W1972199034 hasConceptScore W1972199034C2777761686 @default.
- W1972199034 hasConceptScore W1972199034C2780091579 @default.
- W1972199034 hasConceptScore W1972199034C2780227381 @default.
- W1972199034 hasConceptScore W1972199034C553184892 @default.
- W1972199034 hasConceptScore W1972199034C71924100 @default.
- W1972199034 hasConceptScore W1972199034C79484868 @default.
- W1972199034 hasConceptScore W1972199034C8891405 @default.
- W1972199034 hasIssue "10" @default.
- W1972199034 hasLocation W19721990341 @default.
- W1972199034 hasLocation W19721990342 @default.
- W1972199034 hasOpenAccess W1972199034 @default.
- W1972199034 hasPrimaryLocation W19721990341 @default.
- W1972199034 hasRelatedWork W1506984959 @default.
- W1972199034 hasRelatedWork W2056385328 @default.
- W1972199034 hasRelatedWork W2149871822 @default.
- W1972199034 hasRelatedWork W2167995128 @default.
- W1972199034 hasRelatedWork W2220102944 @default.
- W1972199034 hasRelatedWork W2409441623 @default.
- W1972199034 hasRelatedWork W2417789235 @default.