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- W1972204205 abstract "Lauren Curtis (National Cancer Institute, Bethesda, MD, USA) presented results from a phase 2 study examining different graft versus host disease (GVHD) prophylaxis regimens for patients with haematological malignancies undergoing allogeneic stem cell transplantation. 81 patients were included in the study, 42 were randomised to receive alemtuzumab and ciclosporin (AC) and 39 to tacrolimus, sirolimus, and methotrexate (TMS). The primary endpoint of the study was incidence of severe chronic GVHD, and differed between the two groups (AC 5% [95% CI 1–15] vs TMS 31% [16–47], p=0·0007). Although 3-year overall survival was similar between the two groups (AC 42% [95% CI 28–57] vs TMS 58% [42–73], p=0·20), median overall survival was longer in the TMS group (18·8 months vs 41·7 months), largely driven by disease progression (3-year malignancy progression AC 51% [95% CI 34–65] vs TMS 21% [10–35], p=0·0062). Although AC resulted in fewer incidents of chronic GVHD, Curtis indicated that future studies would concentrate on modifying the TMS regimen. 57th American Society of Hematology Annual MeetingRichard Stone (Dana-Farber Cancer Institute, Boston, MA, USA) presented results from the randomised CALGB 10603 trial on patients with newly diagnosed acute myeloid leukaemia (AML) with FLT3 mutations. Midostaurin is a multikinase inhibitor that can not only target both FLT3-ITD and FLT3-TKD mutations, but also inhibits other kinases, such as VEGFR, KIT, and PDGFR. 3279 patients with AML aged 18–60 years were screened for mutations in FLT3 by central laboratories. 717 patients (341 FLT3 ITD-low, 214 FLT3 ITD-high; 162 FLT3-TKD) received either midostaurin (n=360) or placebo (n=357). Full-Text PDF" @default.
- W1972204205 created "2016-06-24" @default.
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- W1972204205 date "2016-01-01" @default.
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- W1972204205 title "57th American Society of Hematology Annual Meeting" @default.
- W1972204205 doi "https://doi.org/10.1016/s2352-3026(15)00291-4" @default.
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