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• W1972207851 endingPage "950" @default.
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• W1972207851 abstract "We have studied the effect of palmitoylethanolamide (PEA, 2.5 – 30 mg kg−1, i.p.) on upper gastrointestinal transit in control mice and in mice with chronic intestinal inflammation induced by croton oil. PEA significantly and dose-dependently decreased intestinal transit. The inhibitory effect of PEA (10 mg kg−1) was not modified by the cannabinoid CB1 receptor antagonist SR141716A (0.3 mg kg−1, i.p.), the cannabinoid CB2 receptor antagonist SR144528 (1 mg kg−1, i.p.), NG-nitro-L-arginine methyl ester (L-NAME, 25 mg kg−1, i.p.), yohimbine (1 mg kg−1, i.p.), naloxone (2 mg kg−1, i.p.) or hexamethonium (1 mg kg−1, i.p.). PEA levels were significantly decreased in the small intestine of croton oil-treated mice. In these animals, PEA also inhibited motility and this effect was not counteracted by SR141716A (0.3 mg kg−1), or SR144528 (1 mg kg−1). Pre-treatment of mice with the amidase inhibitor phenylmethyl sulphonil fluoride (PMSF, 30 mg kg−1, i.p.) did not modify the inhibitory effect of PEA, either in control or in mice with inflammation. It is concluded that PEA inhibits intestinal motility with a peripheral mechanism independent from cannabinoid receptor activation. The decreased levels of PEA in croton oil-treated might contribute, at least in part, to the exaggerated transit observed during chronic intestinal inflammation. British Journal of Pharmacology (2001) 134, 945–950; doi:10.1038/sj.bjp.0704339" @default.
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• W1972207851 date "2001-11-01" @default.
• W1972207851 modified "2023-10-13" @default.
• W1972207851 title "Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice" @default.
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• W1972207851 doi "https://doi.org/10.1038/sj.bjp.0704339" @default.
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