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- W1972208052 abstract "To elucidate the non-infectious inflammatory etiology of epidural fever. We enrolled a prospective cohort of afebrile (<99.5°F) nulliparas with epidural analgesia, obtaining maternal serum at initiation of epidural analgesia and monitoring maternal core temperatures hourly (n = 71). Students t-test was used as appropriate. In this low-risk cohort, the rate of intrapartum fever >100.4°F was 24%. Pre-epidural maternal IL-6 levels were significantly higher in women who later developed a fever (26.1±4.4 vs. 88.9±21.8 pg/mL, p = .01). The majority of women had no temperature response to epidural analgesia (Figure 1. However, the subset of women who later develop epidural fever manifest temperature changes too soon to be explained by chorioamnionitis. We report the novel finding that only a subset of nulliparous women respond to epidural with hyperthermia, and that this response is not associated with clinical signs of underlying infection. However, there exists antecedant maternal inflammation, as shown by elevated IL-6, prior to epidural placement. Our findings do not support the two previous hypotheses for epidural fever: 1) acquired infection and 2) pertubations of maternal thermoregulation. Elucidating the inflammatory mechanism of epidural fever is critical in designing targeted interventions." @default.
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- W1972208052 date "2003-12-01" @default.
- W1972208052 modified "2023-09-25" @default.
- W1972208052 title "Underlying interleukin-6 levels identify women destined to develop intrapartum fever after epidural analgesia" @default.
- W1972208052 doi "https://doi.org/10.1016/j.ajog.2003.10.515" @default.
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