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- W1972211700 abstract "ABSTRACT. Although triparanol has been shown previously to cause a decrease in urinary 17-hydroxycorticosteroids (17-OHCS) in normal subjects and in patients with Cushing's syndrome, the underlying mechanism has not been established. The present study indicates that triparanol decreases the urinary 17-OHCS by modifying the extra-adrenal metabolism of cortisol. The fall in the urinary 17-OHCS produced by triparanol is not accompanied by a decrease in the plasma 17-OHCS nor by a decrease in the cortisol secretion rate. In addisonian patients maintained on constant doses of exogenous cortisol, triparanol reduces the urinary 17-OHCS to approximately the same degree as in subjects with intact adrenal function. Triparanol does not significantly increase the degree of binding of cortisol by plasma proteins, but it does cause a slight prolongation of the rate of disappearance of tracer doses of 4-C14-cortisol from the plasma of normal subjects. Triparanol has no effect upon the rate of aldosterone secretion nor u..." @default.
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- W1972211700 date "1962-11-01" @default.
- W1972211700 modified "2023-09-27" @default.
- W1972211700 title "Effects of Triparanol on the Secretion and Metabolism of Adrenal Corticosteroids" @default.
- W1972211700 doi "https://doi.org/10.1210/jcem-22-11-1057" @default.
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