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• W1972252092 abstract "Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response effect whereas in the ventral hippocampus and raphe nuclei the fluoxetine-induced effect was maximum at 10 mg/kg. However, the maximal increase in 5-HT was observed in the cell body-containing area, the raphe nuclei. The order of changes in extracellular 5-HT was raphe nuclei > ventral hippocampus > frontal cortex. Our results add further arguments in favour of the key role played by raphe nuclei in the mechanism of action of serotoninergic antidepressant drugs." @default.
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• W1972252092 date "1995-11-01" @default.
• W1972252092 modified "2023-10-17" @default.
• W1972252092 title "Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study" @default.
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• W1972252092 doi "https://doi.org/10.1016/0014-2999(95)00573-4" @default.
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