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- W1972254374 abstract "Although there is evidence that ethanol or one of i ts metabolites can exert a direct toxic effect on hepatocyte function (Rubin & Cederbaum, 1977) and population studies have shown a clear correlation between the amount of alcohol consumed and the incidence of alcoholic cirrhosis (Rubin & Leiber, 1972), there is considerable variation in the individual susceptibility to the hepatotoxic effects of alcohol (Saunders & Uodak eL al, 1977). The key event, pathologically, seems to be the development of alcoholic hepatitis, which progresses to cirrhosis in more than 50% of cases (Galambas, 1972; Helman & Temko eL al, 1971) and can do so despite cessation of alcohol intake. The association between the histocompatibility antigen HAL B8 (a genetic marker of several disorders thought to be immune-mediated) and the mare rapid development of cirrhosis (Saunders & Bodak eL al, 1982), and the increased incidence of some" @default.
- W1972254374 created "2016-06-24" @default.
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- W1972254374 date "1988-01-01" @default.
- W1972254374 modified "2023-09-27" @default.
- W1972254374 title "Relevance of immune mediated mechanisms in progressive alcoholic liver injury" @default.
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- W1972254374 doi "https://doi.org/10.1016/0098-2997(88)90021-0" @default.
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