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- W1972255087 abstract "Abstract The pharmacokinetics of 2-pivaloylindan-1,3-dione (Pival±) after administration of a single dose was investigated in dogs. The plasma concentration graph can be described by a one compartment open model. The drug is fairly well absorbed (67%) and the excretion is extremely slow with a half-life of nearly five days. These kinetics can be explained by the physicochemical properties of the drug, such as strong binding to canine plasma protein, high lipophility and the lack of transformation to polar metabolites. A single oral dose of 5 mg/kg must be regarded as lethal to dogs and the LD50 is assumed to be approximately 4 mg/kg in this species." @default.
- W1972255087 created "2016-06-24" @default.
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- W1972255087 date "2009-03-13" @default.
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- W1972255087 title "Pharmacokinetics of 2-Pivaloylindan-1,3-Dione in Dogs" @default.
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- W1972255087 doi "https://doi.org/10.1111/j.1600-0773.1978.tb02173.x" @default.
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