Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972261909> ?p ?o ?g. }
- W1972261909 endingPage "1072" @default.
- W1972261909 startingPage "1055" @default.
- W1972261909 abstract "The hydroxylation of cholesterol, bile acids, and steroid hormones by liver cytochrome P450 (CYP) enzymes proceeds with a high degree of regiospecificity, and contributes to both biosynthetic and catabolic pathways of sterol metabolism. CYP 7-catalyzed cholesterol 7α-hydroxylation, a key control point of bile acid biosynthesis, is regulated at a pretranslational step, probably transcription initiation, by multiple factors, including liver bile acid and cholesterol levels, thyroid hormone status, and diurnal rhythm. Hydrophobic bile acids, such as lithocholic acid, are converted to less cholestatic derivatives by 6β-hydroxylation carried out by CYP 3A P450s, which also catalyze steroid hormone 6β-hydroxylation reactions. Complex, gender-dependent developmental patterns characterize the expression of steroid 5α-reductase and several rat liver steroid hydroxylase CYPs. Multiple pituitary-dependent factors regulate the expression of these enzymes; of greatest importance are the gonadal steroids and the sex-dependent secretory patterns of growth hormone (GH) that they impart. The continuous presence of GH in circulation, a characteristic of adult female rats, positively regulates expression of the female-specific steroid disulfate 15β-hydroxylase CYP 2C12, while expression of the male-specific steroid 16α- and 2α-hydroxylase CYP 2C11 is stimulated by the intermittent pituitary secretion of GH that occurs in adult male rats. Intermittent GH can stimulate CYP 2C11 gene expression even when the hormone presents to the hepatocyte at a non-physiological pulse amplitude, duration, and frequency, provided that an interpulse interval of no GH (obligatory recovery period) is maintained for at least 2.5 h. GH regulates the expression of the CYP 2C11 and CYP 2C12 genes at the level of transcription initiation. This process is probably mediated by sex-dependent and GH-regulated protein-DNA interactions, such as those observed in the 5′-flank of the CYP 2C12 gene. Thyroid hormone is a second major regulator of liver steroid hydroxylase P450 activity. It regulates these enzymes directly, at a pretranslational step, and indirectly, through its stimulation of pituitary GH secretion and by its positive effects on the expression of the flavoenzyme NADPH-P450 reductase, which catalyzes electron transfer that is obligatory for all microsomal steroid hydroxylation reactions." @default.
- W1972261909 created "2016-06-24" @default.
- W1972261909 creator A5044985980 @default.
- W1972261909 date "1992-12-01" @default.
- W1972261909 modified "2023-10-12" @default.
- W1972261909 title "Regulation of liver-specific steroid metabolizing cytochromes P450: Cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases" @default.
- W1972261909 cites W1455854253 @default.
- W1972261909 cites W1490793506 @default.
- W1972261909 cites W1492298052 @default.
- W1972261909 cites W1493635770 @default.
- W1972261909 cites W1494056096 @default.
- W1972261909 cites W1494303055 @default.
- W1972261909 cites W1499429603 @default.
- W1972261909 cites W1499968189 @default.
- W1972261909 cites W1500814526 @default.
- W1972261909 cites W1508994608 @default.
- W1972261909 cites W1509191323 @default.
- W1972261909 cites W1510784632 @default.
- W1972261909 cites W1526269646 @default.
- W1972261909 cites W1529933235 @default.
- W1972261909 cites W1531280250 @default.
- W1972261909 cites W1532840606 @default.
- W1972261909 cites W1548258669 @default.
- W1972261909 cites W1549399628 @default.
- W1972261909 cites W1550709913 @default.
- W1972261909 cites W1555518546 @default.
- W1972261909 cites W1557519226 @default.
- W1972261909 cites W1566885967 @default.
- W1972261909 cites W1573552069 @default.
- W1972261909 cites W1578577647 @default.
- W1972261909 cites W1583328345 @default.
- W1972261909 cites W1588985663 @default.
- W1972261909 cites W1590889826 @default.
- W1972261909 cites W1598208132 @default.
- W1972261909 cites W1599952788 @default.
- W1972261909 cites W1600065401 @default.
- W1972261909 cites W1600719794 @default.
- W1972261909 cites W1602024000 @default.
- W1972261909 cites W1604915447 @default.
- W1972261909 cites W1605532464 @default.
- W1972261909 cites W1750807446 @default.
- W1972261909 cites W1769791719 @default.
- W1972261909 cites W1825809852 @default.
- W1972261909 cites W1828402659 @default.
- W1972261909 cites W1892479606 @default.
- W1972261909 cites W1943002371 @default.
- W1972261909 cites W1966050085 @default.
- W1972261909 cites W1972771587 @default.
- W1972261909 cites W1973967456 @default.
- W1972261909 cites W1974182505 @default.
- W1972261909 cites W1977635100 @default.
- W1972261909 cites W1981435376 @default.
- W1972261909 cites W1988017648 @default.
- W1972261909 cites W1992369508 @default.
- W1972261909 cites W2002477884 @default.
- W1972261909 cites W2003604055 @default.
- W1972261909 cites W2004145625 @default.
- W1972261909 cites W2008107342 @default.
- W1972261909 cites W2008774679 @default.
- W1972261909 cites W2008892820 @default.
- W1972261909 cites W2015902336 @default.
- W1972261909 cites W2018723007 @default.
- W1972261909 cites W2024901198 @default.
- W1972261909 cites W2025502285 @default.
- W1972261909 cites W2028506307 @default.
- W1972261909 cites W2032359283 @default.
- W1972261909 cites W2033456201 @default.
- W1972261909 cites W2033869721 @default.
- W1972261909 cites W2035013334 @default.
- W1972261909 cites W2037816029 @default.
- W1972261909 cites W2042555886 @default.
- W1972261909 cites W2042593544 @default.
- W1972261909 cites W2045364028 @default.
- W1972261909 cites W2047241297 @default.
- W1972261909 cites W2048071909 @default.
- W1972261909 cites W2048255261 @default.
- W1972261909 cites W2050831441 @default.
- W1972261909 cites W2051175552 @default.
- W1972261909 cites W2051649196 @default.
- W1972261909 cites W2051897188 @default.
- W1972261909 cites W2052160939 @default.
- W1972261909 cites W2052428509 @default.
- W1972261909 cites W2057130915 @default.
- W1972261909 cites W2066322042 @default.
- W1972261909 cites W2066469648 @default.
- W1972261909 cites W2067158315 @default.
- W1972261909 cites W2068187158 @default.
- W1972261909 cites W2068650923 @default.
- W1972261909 cites W2071124826 @default.
- W1972261909 cites W2071296267 @default.
- W1972261909 cites W2082962319 @default.
- W1972261909 cites W2085964709 @default.
- W1972261909 cites W2086423720 @default.
- W1972261909 cites W2089728262 @default.
- W1972261909 cites W2091727102 @default.
- W1972261909 cites W2091783518 @default.
- W1972261909 cites W2092191147 @default.
- W1972261909 cites W2092487388 @default.