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- W1972262019 abstract "The effect of 7,8-diacetoxy-4-methylcoumarin (DAMC) has been studied on hepatic NADPH cytochrome C reductase-- an enzyme participating in the microsomal electron transport. The preincubation of liver microsomes with DAMC resulted in a time-dependent activation of NADPH cytochrome C reductase. The catalytic activity of the enzyme enhanced nearly 600% by 25 microM concentration of DAMC after 10 min of preincubation. The action of DAMC on the reductase resulted in enhanced v(max) while Km remained constant. A plot of 1/v(max) as a function of DAMC concentration resulted in a non-linear, but rectangular hyperbola indicative of hyperbolic activation. DAMC was also proved to be effective in significantly enhancing the activity of NADPH cytochrome C reductase in vivo. 7,8-Dihydroxy-4-methylcoumarin (DHMC), the deacetylated product of DAMC failed to irreversibly activate the enzyme. The activation effect of DAMC upon the enzyme was abolished by p-hydroxymercury benzoate. The role of a transacetylase in transferring the acetyl group of DAMC to the amino acid(s) of the active site of NADPH cytochrome C reductase causing irreversible enzyme activation is enunciated." @default.
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- W1972262019 date "1999-02-01" @default.
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- W1972262019 title "Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part 4: Hyperbolic Activation of Rat Liver Microsomal NADPH-Cytochrome C Reductase by the Novel Acetylator 7,8-Diacetoxy-4-methylcoumarin" @default.
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- W1972262019 doi "https://doi.org/10.1016/s0968-0896(98)00228-4" @default.
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