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- W1972262995 abstract "Objectives . The purpose of this study was to determine whether infarct-related coronary artery patency influence myocardial electrical stability as measured by the prevalence of late potentials or heart rate variability. Background . Several studies have suggested that loss of vagal activity is associated with an increased incidence of arrhythmic death after myocardial infarction. Methods . A short-duration, high resolution electrocardiogram (ECG) was performed before hospital discharge in 175 patients with a first myocardial infarction. Seventy-three patients received thrombolytic therapy. All patients underwent coronary angiography. Coronary occlusion was defined as minimal or no anterograde flow. Eighty-eight patients (50.3%) had an occluded infarct-related artery. Sixty-two healthy subjects served as control subjects to determine the normal range of heart rate variability. Results . Comparison between the control group and patients without patency of the infarct-related artery in the time domain and spectral analyses revealed in the latter patients a reduced heart rate variability (p < 0.0001) and a lower power spectrum density in both the 0.05- to 0.15-Hz band (p < 0.0001) and the 0.15- to 0.35-Hz band (p < 0.0001). The heart rate variability in patient with late potentials was lower than in those with a normal signal-averaged ECG. Those patients with spontaneous or thrombolysis-induced reperfusion have less occurrence of late potentials and higher parasympathetic activity than do patients with a closed artery. Conclusions . This study suggests that the patency of the infarct-related artery determines both the absence of late potentials and the preservation of vagal tone and may explain the reduction in mortality induced by thrombolytic therapy in myocardial infarction." @default.
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- W1972262995 date "1993-09-01" @default.
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- W1972262995 title "Influence of infarct-related artery patency on the indexes of parasympathetic activity and prevalence of late potentials in survivors of acute myocardial infarction" @default.
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- W1972262995 doi "https://doi.org/10.1016/0735-1097(93)90179-5" @default.
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