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• W1972266852 startingPage "1287" @default.
• W1972266852 abstract "Dipalmitoylphosphatidylcholine (DPPC) liposomes were employed as membrane models for the investigation of the interaction occurring between methotrexate (MTX) and bilayer lipid matrix. Liposomes were obtained by hydrating a lipid film with 50 mM Tris buffer (pH 7.4). The differential scanning calorimetry (DSC) evaluation of the thermotropic parameters associated with the phase transitions of DPPC liposomes gave useful information about the kind of drug-membrane interaction. The results showed an electrostatic interaction taking place with the negatively charged molecules of MTX and the phosphorylcholine head groups, constituting the outer part of DPPC bilayers. No interaction with the hydrophobic phospholipid bilayer domains was detected, revealing a poor capability of MTX to cross through lipid membranes to reach the interior compartment of a lipid bounded structure. These findings correlate well within vitro biological experiments on MTX cell susceptibility." @default.
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• W1972266852 date "1995-06-01" @default.
• W1972266852 modified "2023-10-01" @default.
• W1972266852 title "Methotrexate interaction with a lipid membrane model of DPPC" @default.
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• W1972266852 doi "https://doi.org/10.1007/bf02549218" @default.
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