FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972275697> ?p ?o ?g. }

• W1972275697 abstract "Background: Mucinous ovarian carcinomas (MC) and mucinous borderline ovarian tumours (MBOT) are associated with ERBB2 amplification and KRAS activating mutations. These events occur in a near-mutually exclusive pattern, and KRAS mutations are more prevalent in MBOTs than MC9s whereas ERBB2 amplification is more frequently seen in MCs. Frequencies of mutations in other oncogenes and tumour suppressor genes in MC are not well established though TP53, BRAF, NRAS, and CDKN2A mutations have all been reported. As these carcinomas are commonly chemo-resistant a definitive molecular categorization of this subtype is needed as treatment options are explored. Methods: We undertook review of pathology reports and after exclusion of potential gastric, appendiceal or pancreatic involvement over 100 mucinous ovarian tumours were identified. HPV testing was undertaken to exclude rare metastasis from endocervical primary site. All specimens were assayed for p53 expression via TMA and subject to sequencing of common cancer gene hotspots using Ion-Torrent or Illumina MiSeq. Previously derived data on ERBB2 status was combined in our analysis and, where available, samples showing heterogeneity of ERBB2 amplification and any other Ras-pathway activating mutation were microdissected with components evaluated independently for concurrent hotspot mutations. Results: All samples were consistent with mucinous tumours of ovarian origin and none were HPV positive. We detected mutations in KRAS, BRAF, CDKN2A, TP53, PTEN, PIK3CA as well as presumed somatic/detrimental, variants in APC that have not previously been reported in mucinous tumours. Despite some samples having enriched tumour content, lower than expected allelic frequencies of KRAS activating mutations suggested intra-tumoural heterogeneity. This was consistent with results observed previously with rare ERBB2 amplification coinciding KRAS mutations. Conclusions: The prevalence of Ras-pathway mutations, especially amongst borderline lesions, suggests these mutations are critical for tumour onset. However varying allelic frequencies of KRAS mutations suggest progression to carcinoma is strongly influenced by other molecular features. Citation Format: Michael S. Anglesio, Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin Kipp, Jaoquin Garcia, Jesse S. Voss, Kevin Halling, Sarah Kerr, Janine Senz, Winnie Yang, Magnus von Knebel Doeberitz, Elena-Sophie Prigge, Miriam Reuschenbach, Anna V. Tinker, Blake Gilks, Jamie N. Bakkum-Gamez, David G. Huntsman, Jessica N. McAlpine. Defining ovarian mucinous tumors: Cancer genes and heterogeneity. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr A18." @default.
• W1972275697 created "2016-06-24" @default.
• W1972275697 creator A5007438121 @default.
• W1972275697 creator A5009116026 @default.
• W1972275697 creator A5009617807 @default.
• W1972275697 creator A5018373201 @default.
• W1972275697 creator A5023410987 @default.
• W1972275697 creator A5024936471 @default.
• W1972275697 creator A5026586433 @default.
• W1972275697 creator A5031945893 @default.
• W1972275697 creator A5037755270 @default.
• W1972275697 creator A5063215428 @default.
• W1972275697 creator A5067283035 @default.
• W1972275697 creator A5068044534 @default.
• W1972275697 creator A5069460356 @default.
• W1972275697 creator A5070771967 @default.
• W1972275697 creator A5075185869 @default.
• W1972275697 creator A5078857320 @default.
• W1972275697 creator A5081676809 @default.
• W1972275697 creator A5085086748 @default.
• W1972275697 creator A5090474147 @default.
• W1972275697 date "2013-10-01" @default.
• W1972275697 modified "2023-09-25" @default.
• W1972275697 title "Abstract A18: Defining ovarian mucinous tumors: Cancer genes and heterogeneity" @default.
• W1972275697 doi "https://doi.org/10.1158/1078-0432.ovca13-a18" @default.
• W1972275697 hasPublicationYear "2013" @default.
• W1972275697 type Work @default.
• W1972275697 sameAs 1972275697 @default.
• W1972275697 citedByCount "0" @default.
• W1972275697 crossrefType "proceedings-article" @default.
• W1972275697 hasAuthorship W1972275697A5007438121 @default.
• W1972275697 hasAuthorship W1972275697A5009116026 @default.
• W1972275697 hasAuthorship W1972275697A5009617807 @default.
• W1972275697 hasAuthorship W1972275697A5018373201 @default.
• W1972275697 hasAuthorship W1972275697A5023410987 @default.
• W1972275697 hasAuthorship W1972275697A5024936471 @default.
• W1972275697 hasAuthorship W1972275697A5026586433 @default.
• W1972275697 hasAuthorship W1972275697A5031945893 @default.
• W1972275697 hasAuthorship W1972275697A5037755270 @default.
• W1972275697 hasAuthorship W1972275697A5063215428 @default.
• W1972275697 hasAuthorship W1972275697A5067283035 @default.
• W1972275697 hasAuthorship W1972275697A5068044534 @default.
• W1972275697 hasAuthorship W1972275697A5069460356 @default.
• W1972275697 hasAuthorship W1972275697A5070771967 @default.
• W1972275697 hasAuthorship W1972275697A5075185869 @default.
• W1972275697 hasAuthorship W1972275697A5078857320 @default.
• W1972275697 hasAuthorship W1972275697A5081676809 @default.
• W1972275697 hasAuthorship W1972275697A5085086748 @default.
• W1972275697 hasAuthorship W1972275697A5090474147 @default.
• W1972275697 hasConcept C104317684 @default.
• W1972275697 hasConcept C121608353 @default.
• W1972275697 hasConcept C142724271 @default.
• W1972275697 hasConcept C190283241 @default.
• W1972275697 hasConcept C21790070 @default.
• W1972275697 hasConcept C2777609662 @default.
• W1972275697 hasConcept C2777874381 @default.
• W1972275697 hasConcept C2780265364 @default.
• W1972275697 hasConcept C2780427987 @default.
• W1972275697 hasConcept C2781182431 @default.
• W1972275697 hasConcept C2781187634 @default.
• W1972275697 hasConcept C501734568 @default.
• W1972275697 hasConcept C502942594 @default.
• W1972275697 hasConcept C54355233 @default.
• W1972275697 hasConcept C71924100 @default.
• W1972275697 hasConcept C86554907 @default.
• W1972275697 hasConcept C86803240 @default.
• W1972275697 hasConceptScore W1972275697C104317684 @default.
• W1972275697 hasConceptScore W1972275697C121608353 @default.
• W1972275697 hasConceptScore W1972275697C142724271 @default.
• W1972275697 hasConceptScore W1972275697C190283241 @default.
• W1972275697 hasConceptScore W1972275697C21790070 @default.
• W1972275697 hasConceptScore W1972275697C2777609662 @default.
• W1972275697 hasConceptScore W1972275697C2777874381 @default.
• W1972275697 hasConceptScore W1972275697C2780265364 @default.
• W1972275697 hasConceptScore W1972275697C2780427987 @default.
• W1972275697 hasConceptScore W1972275697C2781182431 @default.
• W1972275697 hasConceptScore W1972275697C2781187634 @default.
• W1972275697 hasConceptScore W1972275697C501734568 @default.
• W1972275697 hasConceptScore W1972275697C502942594 @default.
• W1972275697 hasConceptScore W1972275697C54355233 @default.
• W1972275697 hasConceptScore W1972275697C71924100 @default.
• W1972275697 hasConceptScore W1972275697C86554907 @default.
• W1972275697 hasConceptScore W1972275697C86803240 @default.
• W1972275697 hasLocation W19722756971 @default.
• W1972275697 hasOpenAccess W1972275697 @default.
• W1972275697 hasPrimaryLocation W19722756971 @default.
• W1972275697 hasRelatedWork W1595859711 @default.
• W1972275697 hasRelatedWork W1601126056 @default.
• W1972275697 hasRelatedWork W1897062612 @default.
• W1972275697 hasRelatedWork W1967113174 @default.
• W1972275697 hasRelatedWork W1992222912 @default.
• W1972275697 hasRelatedWork W1998897501 @default.
• W1972275697 hasRelatedWork W2052987700 @default.
• W1972275697 hasRelatedWork W2065281297 @default.
• W1972275697 hasRelatedWork W2140180407 @default.
• W1972275697 hasRelatedWork W2337849629 @default.
• W1972275697 hasRelatedWork W2407450722 @default.
• W1972275697 hasRelatedWork W2410897497 @default.
• W1972275697 hasRelatedWork W2472949987 @default.
• W1972275697 hasRelatedWork W2484461725 @default.

• next