FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972277006> ?p ?o ?g. }

• W1972277006 endingPage "547" @default.
• W1972277006 startingPage "541" @default.
• W1972277006 abstract "Anti-mitochondrial antibodies (anti-M7) in sera from patients with dilated cardiomyopathy and myocarditis recognize, besides mitochondrial antigens, bacterial sarcosine dehydrogenase. The common target antigen was identified as the covalently bound FAD of mitochondrial and bacterial flavoenzymes. Thus, anti-M7-positive serum reacted on Western blots exclusively with covalently flavinylated enzymes. The antigenic specificity of anti-M7 sera was reproduced by an antiserum raised in rabbits with 6-hydroxy-D-nicotine oxidase. The heart mitochondrial membrane antigen recognized by anti-M7 serum was identified as the flavoprotein subunit of succinate dehydrogenase, the antigens in rat liver mitochondrial matrix as the flavoenzymes dimethylglycine dehydrogenase and sarcosine dehydrogenase. Anti-M7 serum contained a specific anti-flavoenzyme antibody fraction. Nanomolar concentrations of FAD and riboflavin inhibited the immune reaction on Western blots and in ELISA, and incubation with FAD-agarose depleted the anti-M7 activity of the serum. N-terminally deleted dimethylglycine dehydrogenase proteins were only immunoprecipitated by anti-M7 sera when the FAD was covalently incorporated. An affinity constant (KD) of 10(-8) M was established for the anti-flavoenzyme antibodies by competitive ELISA. Of patients with cardiomyopathy and myocarditis, 36% and 25%, respectively, were anti-flavoenzyme-positive by Western blot and ELISA, but only two of 15 patients with other heart diseases and none of 50 healthy controls." @default.
• W1972277006 created "2016-06-24" @default.
• W1972277006 creator A5004589888 @default.
• W1972277006 creator A5011447416 @default.
• W1972277006 creator A5022754351 @default.
• W1972277006 creator A5035214663 @default.
• W1972277006 creator A5045408805 @default.
• W1972277006 creator A5058412971 @default.
• W1972277006 date "1998-03-01" @default.
• W1972277006 modified "2023-10-18" @default.
• W1972277006 title "Anti-mitochondrial antibodies in patients with dilated cardiomyopathy (anti-M7) are directed against flavoenzymes with covalently bound FAD" @default.
• W1972277006 cites W111329052 @default.
• W1972277006 cites W1516041179 @default.
• W1972277006 cites W1527657941 @default.
• W1972277006 cites W1548692828 @default.
• W1972277006 cites W1565286226 @default.
• W1972277006 cites W1967567913 @default.
• W1972277006 cites W1971623736 @default.
• W1972277006 cites W1972922050 @default.
• W1972277006 cites W1976069206 @default.
• W1972277006 cites W1981440926 @default.
• W1972277006 cites W2014102565 @default.
• W1972277006 cites W2015438031 @default.
• W1972277006 cites W2018289835 @default.
• W1972277006 cites W2020136934 @default.
• W1972277006 cites W2041205485 @default.
• W1972277006 cites W2043263840 @default.
• W1972277006 cites W2046054174 @default.
• W1972277006 cites W2071053574 @default.
• W1972277006 cites W2075905433 @default.
• W1972277006 cites W2076525857 @default.
• W1972277006 cites W2100837269 @default.
• W1972277006 cites W2131303188 @default.
• W1972277006 cites W2148404862 @default.
• W1972277006 cites W2160563582 @default.
• W1972277006 cites W2404417611 @default.
• W1972277006 cites W2418410798 @default.
• W1972277006 cites W2912962615 @default.
• W1972277006 cites W3873766 @default.
• W1972277006 cites W937204623 @default.
• W1972277006 doi "https://doi.org/10.1046/j.1365-2249.1998.00531.x" @default.
• W1972277006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1904892" @default.
• W1972277006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9528896" @default.
• W1972277006 hasPublicationYear "1998" @default.
• W1972277006 type Work @default.
• W1972277006 sameAs 1972277006 @default.
• W1972277006 citedByCount "29" @default.
• W1972277006 countsByYear W19722770062014 @default.
• W1972277006 countsByYear W19722770062017 @default.
• W1972277006 countsByYear W19722770062019 @default.
• W1972277006 countsByYear W19722770062021 @default.
• W1972277006 countsByYear W19722770062022 @default.
• W1972277006 crossrefType "journal-article" @default.
• W1972277006 hasAuthorship W1972277006A5004589888 @default.
• W1972277006 hasAuthorship W1972277006A5011447416 @default.
• W1972277006 hasAuthorship W1972277006A5022754351 @default.
• W1972277006 hasAuthorship W1972277006A5035214663 @default.
• W1972277006 hasAuthorship W1972277006A5045408805 @default.
• W1972277006 hasAuthorship W1972277006A5058412971 @default.
• W1972277006 hasBestOaLocation W19722770062 @default.
• W1972277006 hasConcept C104317684 @default.
• W1972277006 hasConcept C147483822 @default.
• W1972277006 hasConcept C153911025 @default.
• W1972277006 hasConcept C159654299 @default.
• W1972277006 hasConcept C185592680 @default.
• W1972277006 hasConcept C203014093 @default.
• W1972277006 hasConcept C2776415932 @default.
• W1972277006 hasConcept C55493867 @default.
• W1972277006 hasConcept C85265743 @default.
• W1972277006 hasConcept C86803240 @default.
• W1972277006 hasConceptScore W1972277006C104317684 @default.
• W1972277006 hasConceptScore W1972277006C147483822 @default.
• W1972277006 hasConceptScore W1972277006C153911025 @default.
• W1972277006 hasConceptScore W1972277006C159654299 @default.
• W1972277006 hasConceptScore W1972277006C185592680 @default.
• W1972277006 hasConceptScore W1972277006C203014093 @default.
• W1972277006 hasConceptScore W1972277006C2776415932 @default.
• W1972277006 hasConceptScore W1972277006C55493867 @default.
• W1972277006 hasConceptScore W1972277006C85265743 @default.
• W1972277006 hasConceptScore W1972277006C86803240 @default.
• W1972277006 hasIssue "3" @default.
• W1972277006 hasLocation W19722770061 @default.
• W1972277006 hasLocation W19722770062 @default.
• W1972277006 hasLocation W19722770063 @default.
• W1972277006 hasOpenAccess W1972277006 @default.
• W1972277006 hasPrimaryLocation W19722770061 @default.
• W1972277006 hasRelatedWork W2026330327 @default.
• W1972277006 hasRelatedWork W2064471734 @default.
• W1972277006 hasRelatedWork W2070751542 @default.
• W1972277006 hasRelatedWork W2073124121 @default.
• W1972277006 hasRelatedWork W2265983845 @default.
• W1972277006 hasRelatedWork W2366316647 @default.
• W1972277006 hasRelatedWork W3010814583 @default.
• W1972277006 hasRelatedWork W3037338813 @default.
• W1972277006 hasRelatedWork W4295879833 @default.
• W1972277006 hasRelatedWork W70981667 @default.
• W1972277006 hasVolume "111" @default.
• W1972277006 isParatext "false" @default.

• next