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- W1972283485 abstract "Baseline brain structural abnormality in patients with Alzheimer's disease (AD) has been reported and is predictive of rate of progression of AD (Kinkingnehum, et al, Neurology 2008). We used voxel based morphometry (VBM) to investigate the association of the degree of severity of AD with the magnetic resonance imaging (MRI) measured regional gray matter volume of brain. MRI T1 weighted images for 9 patients (mini-mental state exam, MMSE, ranged from 6 to18) and 14 normal control (NC) subjects were acquired. Data pre-processing and analysis were performed using VBM8 toolbox in SPM8. The procedure involved the segmentation of tissue classes, spatial normalization of all images into a standard space, modulation to compensate for the effect of spatial normalization, and smoothing to increase signal to noise ratios. Then the voxel-wise statistical analysis was designed to compare the regional gray matter volume differences between AD and NC groups, and moreover, to examine the association of the regional gray matter volume variation with the disease severity indexed with MMSE using linear regression within the AD group. There were no age, gender, education difference between AD and NC. Consistent with a number of previous studies, VBM group analysis revealed a significant AD related regional gray matter volume decrease in various brain regions in temporal, parietal, occipital and frontal lobes, such as amygdale, hippocampus, parahippocampus, fusiform, postcentral gyrus and posterior cingulate (p < 0.001, uncorrected). In AD patients, MMSE was found to associate with decreased regional gray matter volumes in regions such as precuneus, cuneus, calcarine, lingual gyrus, hippocampus and parahippocampal gyrus (p-values ranged 6.0 to 0.001, uncorrected)." @default.
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- W1972283485 date "2011-07-01" @default.
- W1972283485 modified "2023-09-27" @default.
- W1972283485 title "P1-360: Association of disease severity with VBM measured reduced regional gray matter volumes in Alzheimer's disease patients" @default.
- W1972283485 doi "https://doi.org/10.1016/j.jalz.2011.05.640" @default.
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