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- W1972284685 endingPage "86" @default.
- W1972284685 startingPage "79" @default.
- W1972284685 abstract "The concept that adult stem cells, despite their impressive proliferative potential, are immortal has been challenged by experimental studies of hematopoietic stem cells. In this review, we discuss the properties that characterize a stem cell, the growing list of tissues in which stem cells are found, how they can be identified and isolated, how stem cells may transdifferentiate, and the findings that illustrate how age affects the hematopoietic stem cell population. We propose that an aging stem cell population affects tissue and organ homeostasis, particularly in response to environmental stresses, and we hypothesize that through this mechanism the functional status of stem cells affects the longevity of the organism." @default.
- W1972284685 created "2016-06-24" @default.
- W1972284685 creator A5025350377 @default.
- W1972284685 creator A5063070865 @default.
- W1972284685 date "2002-04-01" @default.
- W1972284685 modified "2023-10-16" @default.
- W1972284685 title "Stem cells from birth to death: The history and the future" @default.
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- W1972284685 doi "https://doi.org/10.1007/s11357-002-0006-z" @default.
- W1972284685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3455756" @default.
- W1972284685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23604899" @default.