Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972285334> ?p ?o ?g. }
- W1972285334 endingPage "269" @default.
- W1972285334 startingPage "244" @default.
- W1972285334 abstract "Abstract Expression of the cellular prion protein (PrP c ) by host cells is required for prion replication and neuroinvasion in transmissible spongiform encephalopathies. As a consequence, identification of the cell types expressing PrP c is necessary to determine the target cells involved in the cerebral propagation of prion diseases. To identify the cells expressing PrP c in the mouse brain, the immunocytochemical localization of PrP c was investigated at the cellular and ultrastructural levels in several brain regions. In addition, we analyzed the expression pattern of a green fluorescent protein reporter gene under the control of regulatory sequences of the bovine prion protein gene in the brain of transgenic mice. By using a preembedding immunogold technique, neuronal PrP c was observed mainly bound to the cell surface and presynaptic sites. Dictyosomes and recycling organelles in most of the major neuron types also exhibited PrP c antigen. In the olfactory bulb, neocortex, putamen, hippocampus, thalamus, and cerebellum, the distribution pattern of both green fluorescent protein and PrP c immunoreactivity suggested that the transgenic regulatory sequences of the bovine PrP gene were sufficient to promote expression of the reporter gene in neurons that express immunodetectable endogenous PrP c . Transgenic mice expressing PrP‐GFP may thus provide attractive murine models for analyzing the transcriptional activity of the Prnp gene during prion infections as well as the anatomopathological kinetics of prion diseases. J. Comp. Neurol. 473:244–269, 2004. © 2004 Wiley‐Liss, Inc." @default.
- W1972285334 created "2016-06-24" @default.
- W1972285334 creator A5000551070 @default.
- W1972285334 creator A5006478341 @default.
- W1972285334 creator A5013369432 @default.
- W1972285334 creator A5021813238 @default.
- W1972285334 creator A5024763483 @default.
- W1972285334 creator A5028794353 @default.
- W1972285334 creator A5053476939 @default.
- W1972285334 creator A5062848552 @default.
- W1972285334 creator A5067478096 @default.
- W1972285334 creator A5071369025 @default.
- W1972285334 date "2004-04-15" @default.
- W1972285334 modified "2023-10-17" @default.
- W1972285334 title "Prion protein (PrP<sup>c</sup>) immunocytochemistry and expression of the green fluorescent protein reporter gene under control of the bovine PrP gene promoter in the mouse brain" @default.
- W1972285334 cites W1486954436 @default.
- W1972285334 cites W1501494207 @default.
- W1972285334 cites W1549404680 @default.
- W1972285334 cites W1550540174 @default.
- W1972285334 cites W1561445208 @default.
- W1972285334 cites W1570234185 @default.
- W1972285334 cites W1819988191 @default.
- W1972285334 cites W1975100045 @default.
- W1972285334 cites W1977167350 @default.
- W1972285334 cites W1979643175 @default.
- W1972285334 cites W1979857580 @default.
- W1972285334 cites W1981250435 @default.
- W1972285334 cites W1981995797 @default.
- W1972285334 cites W1982013273 @default.
- W1972285334 cites W1983345119 @default.
- W1972285334 cites W1983750916 @default.
- W1972285334 cites W1985134652 @default.
- W1972285334 cites W1985273834 @default.
- W1972285334 cites W1989989032 @default.
- W1972285334 cites W1991433245 @default.
- W1972285334 cites W1992084965 @default.
- W1972285334 cites W1992380356 @default.
- W1972285334 cites W1994142447 @default.
- W1972285334 cites W1995292786 @default.
- W1972285334 cites W1995673366 @default.
- W1972285334 cites W1997725693 @default.
- W1972285334 cites W1997781327 @default.
- W1972285334 cites W1998038512 @default.
- W1972285334 cites W1998358216 @default.
- W1972285334 cites W2000036908 @default.
- W1972285334 cites W2001306764 @default.
- W1972285334 cites W2006810449 @default.
- W1972285334 cites W2008004502 @default.
- W1972285334 cites W2010184287 @default.
- W1972285334 cites W2013260472 @default.
- W1972285334 cites W2014924970 @default.
- W1972285334 cites W2015829540 @default.
- W1972285334 cites W2018675827 @default.
- W1972285334 cites W2023462803 @default.
- W1972285334 cites W2029428782 @default.
- W1972285334 cites W2032379145 @default.
- W1972285334 cites W2036645353 @default.
- W1972285334 cites W2036851625 @default.
- W1972285334 cites W2037800837 @default.
- W1972285334 cites W2038139001 @default.
- W1972285334 cites W2042368222 @default.
- W1972285334 cites W2042978244 @default.
- W1972285334 cites W2043601483 @default.
- W1972285334 cites W2046487370 @default.
- W1972285334 cites W2049627175 @default.
- W1972285334 cites W2051968416 @default.
- W1972285334 cites W2052901299 @default.
- W1972285334 cites W2053636966 @default.
- W1972285334 cites W2057439911 @default.
- W1972285334 cites W2060941647 @default.
- W1972285334 cites W2061688435 @default.
- W1972285334 cites W2064303517 @default.
- W1972285334 cites W2065998229 @default.
- W1972285334 cites W2072565832 @default.
- W1972285334 cites W2077342512 @default.
- W1972285334 cites W2077657292 @default.
- W1972285334 cites W2078365170 @default.
- W1972285334 cites W2080225301 @default.
- W1972285334 cites W2083734018 @default.
- W1972285334 cites W2086476997 @default.
- W1972285334 cites W2094929448 @default.
- W1972285334 cites W2095221909 @default.
- W1972285334 cites W2095414734 @default.
- W1972285334 cites W2115912299 @default.
- W1972285334 cites W2119365367 @default.
- W1972285334 cites W2122191525 @default.
- W1972285334 cites W2122708921 @default.
- W1972285334 cites W2125522501 @default.
- W1972285334 cites W2126165786 @default.
- W1972285334 cites W2127810309 @default.
- W1972285334 cites W2128781491 @default.
- W1972285334 cites W2134658084 @default.
- W1972285334 cites W2135144826 @default.
- W1972285334 cites W2147966233 @default.
- W1972285334 cites W2150524206 @default.
- W1972285334 cites W2152735279 @default.
- W1972285334 cites W2152958744 @default.
- W1972285334 cites W2153499210 @default.