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• W1972287997 abstract "<b>Objective</b> To assess the effect of weight loss induced by a very low energy diet on moderate and severe obstructive sleep apnoea in obese men. <b>Design </b>Single centre, two arm, parallel, randomised, controlled, open label trial. Blocked randomisation procedure used for treatment allocation. <b>Setting </b>Outpatient obesity clinic in a university hospital in Stockholm, Sweden. <b>Participants </b>63 obese men (body mass index 30-40, age 30-65 years) with moderate to severe obstructive sleep apnoea (apnoea-hypopnoea index (AHI) ≥15), treated with continuous positive airway pressure. <b>Interventions</b> The intervention group received a liquid very low energy diet (2.3 MJ/day) for seven weeks to promote weight loss, followed by two weeks of gradual introduction of normal food, reaching 6.3 MJ/day at week 9. The control group adhered to their usual diet during the nine weeks of follow-up. <b>Main outcome measure</b> AHI, the major disease severity index for obstructive sleep apnoea. Data from all randomised patients were included in an intention to treat analysis (baseline carried forward for missing data). <b>Results </b>Of the 63 eligible patients, 30 were randomised to intervention and 33 to control. Two patients in the control group were dissatisfied with allocation and immediately discontinued. All other patients completed the trial. Both groups had a mean AHI of 37 events/h (SD 15) at baseline. At week 9, the intervention group’s mean body weight was 20 kg (95% confidence interval 18 to 21) lower than that of the control group, while its mean AHI was 23 events/h (15 to 30) lower. In the intervention group, five of 30 (17%) were disease free after the energy restricted diet (AHI <5), with 15 of 30 (50%) having mild disease (AHI 5-14.9), whereas the AHI of all patients in the control group except one remained at 15 or higher. In a subgroup analysis of the intervention group, baseline AHI significantly modified the effectiveness of treatment, with a greater improvement in AHI in patients with severe obstructive sleep apnoea (AHI >30) at baseline compared with those with moderate (AHI 15-30) sleep apnoea (AHI −38 <i>v</i> −12, P<0.001), despite similar weight loss (−19.2 <i>v</i> −18.2 kg, P=0.55). <b>Conclusion </b>Treatment with a low energy diet improved obstructive sleep apnoea in obese men, with the greatest effect in patients with severe disease. Long term treatment studies are needed to validate weight loss as a primary treatment strategy for obstructive sleep apnoea. <b>Trial registration</b> Current Controlled Trials ISRCTN70090382." @default.
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• W1972287997 date "2009-12-03" @default.
• W1972287997 modified "2023-10-01" @default.
• W1972287997 title "Effect of a very low energy diet on moderate and severe obstructive sleep apnoea in obese men: a randomised controlled trial" @default.
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• W1972287997 doi "https://doi.org/10.1136/bmj.b4609" @default.
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