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• W1972296656 abstract "Hypothalamic mRNA and peptide levels of pro-opio-melanocortin (POMC) and other neuropeptides were studied in rats that either develop obesity (diet-induced obese, DIO), when fed a palatable and hypercaloric diet (cafeteria diet, caf) or do not develop obesity (diet resistant, DR), when fed the same diet. cafDIO rats showed a significant increase in POMC, but not in melanin concentrating hormone, mRNA levels as determined by semiquantitative in situ hybridization. cafDR and cafDIO rats showed no change in POMC-derived peptide levels, whereas neuropeptide Y immunoreactivity was significantly increased in cafDR rats. POMC mRNA levels were also studied in high-fat diet-fed rats but no significant change was observed. Altered hypothalamic transmission by POMC-derived peptides may contribute to the susceptibility of cafDIO rats to the weight promoting action of caf diet." @default.
• W1972296656 created "2016-06-24" @default.
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• W1972296656 date "2002-06-01" @default.
• W1972296656 modified "2023-10-04" @default.
• W1972296656 title "Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamus" @default.
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• W1972296656 doi "https://doi.org/10.1016/s0196-9781(02)00030-x" @default.
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