FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972300934> ?p ?o ?g. }

• W1972300934 endingPage "3737" @default.
• W1972300934 startingPage "3733" @default.
• W1972300934 abstract "We have studied whether the origin of retroviral onc genes, by transduction of sequences from cellular proto-onc genes, involves DNA or RNA recombination. By using altered Harvey sarcoma proviruses as models for transduction intermediates, we have investigated the mechanism of regeneration of transforming virus from truncated proviruses with only a single 5' long terminal repeat (LTR) but with a complete 5'-LTR-ras transforming gene. The Harvey proviruses were specifically altered to discriminate between virus regeneration by RNA template switching during reverse transcription, as has been postulated, and virus regeneration by DNA recombination with either helper virus or among elements of the defective provirus alone. For this purpose U3 elements of the Harvey proviral LTR, which are essential for replication but not for transcription, were deleted in vitro. Only proviral constructions with an intact or a nearly intact single LTR regenerated infectious Harvey sarcoma virus. Since all constructions transformed cells and produced identical RNAs, our results exclude a model of virus regeneration by switching of RNA templates during reverse transcription. We conclude that regeneration of infectious Harvey viruses from truncated provirus involved illegitimate recombination of cellular or cotransfected DNAs flanking the 5'-LTR-ras gene of Harvey sarcoma virus. Based on this and evidence from the literature, we propose that retroviral transduction proceeds by way of rare illegitimate recombinations between proviral and cellular DNAs." @default.
• W1972300934 created "2016-06-24" @default.
• W1972300934 creator A5006539902 @default.
• W1972300934 creator A5010111166 @default.
• W1972300934 date "1988-06-01" @default.
• W1972300934 modified "2023-09-25" @default.
• W1972300934 title "Retroviral transduction of oncogenic sequences involves viral DNA instead of RNA." @default.
• W1972300934 cites W1493851519 @default.
• W1972300934 cites W1517297753 @default.
• W1972300934 cites W1559513140 @default.
• W1972300934 cites W1599461709 @default.
• W1972300934 cites W1713048017 @default.
• W1972300934 cites W1720727101 @default.
• W1972300934 cites W1800768404 @default.
• W1972300934 cites W1973393468 @default.
• W1972300934 cites W1974455897 @default.
• W1972300934 cites W1981327220 @default.
• W1972300934 cites W1988178079 @default.
• W1972300934 cites W1993382464 @default.
• W1972300934 cites W2000712906 @default.
• W1972300934 cites W2002842607 @default.
• W1972300934 cites W2005386705 @default.
• W1972300934 cites W2018953874 @default.
• W1972300934 cites W2045381877 @default.
• W1972300934 cites W2060651643 @default.
• W1972300934 cites W2061563589 @default.
• W1972300934 cites W2063085217 @default.
• W1972300934 cites W2077421380 @default.
• W1972300934 cites W2084818621 @default.
• W1972300934 cites W2085600928 @default.
• W1972300934 cites W2094657382 @default.
• W1972300934 cites W2103110137 @default.
• W1972300934 cites W2104417677 @default.
• W1972300934 cites W2118929543 @default.
• W1972300934 cites W2135380694 @default.
• W1972300934 cites W2154632774 @default.
• W1972300934 cites W2156662927 @default.
• W1972300934 cites W2180795626 @default.
• W1972300934 doi "https://doi.org/10.1073/pnas.85.11.3733" @default.
• W1972300934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/280292" @default.
• W1972300934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2836857" @default.
• W1972300934 hasPublicationYear "1988" @default.
• W1972300934 type Work @default.
• W1972300934 sameAs 1972300934 @default.
• W1972300934 citedByCount "26" @default.
• W1972300934 countsByYear W19723009342018 @default.
• W1972300934 countsByYear W19723009342022 @default.
• W1972300934 crossrefType "journal-article" @default.
• W1972300934 hasAuthorship W1972300934A5006539902 @default.
• W1972300934 hasAuthorship W1972300934A5010111166 @default.
• W1972300934 hasBestOaLocation W19723009341 @default.
• W1972300934 hasConcept C102906071 @default.
• W1972300934 hasConcept C104317684 @default.
• W1972300934 hasConcept C138885662 @default.
• W1972300934 hasConcept C141231307 @default.
• W1972300934 hasConcept C144001008 @default.
• W1972300934 hasConcept C15152581 @default.
• W1972300934 hasConcept C153911025 @default.
• W1972300934 hasConcept C156719811 @default.
• W1972300934 hasConcept C159047783 @default.
• W1972300934 hasConcept C16184334 @default.
• W1972300934 hasConcept C179926584 @default.
• W1972300934 hasConcept C199491388 @default.
• W1972300934 hasConcept C2522874641 @default.
• W1972300934 hasConcept C41895202 @default.
• W1972300934 hasConcept C54355233 @default.
• W1972300934 hasConcept C552990157 @default.
• W1972300934 hasConcept C55493867 @default.
• W1972300934 hasConcept C67705224 @default.
• W1972300934 hasConcept C86803240 @default.
• W1972300934 hasConceptScore W1972300934C102906071 @default.
• W1972300934 hasConceptScore W1972300934C104317684 @default.
• W1972300934 hasConceptScore W1972300934C138885662 @default.
• W1972300934 hasConceptScore W1972300934C141231307 @default.
• W1972300934 hasConceptScore W1972300934C144001008 @default.
• W1972300934 hasConceptScore W1972300934C15152581 @default.
• W1972300934 hasConceptScore W1972300934C153911025 @default.
• W1972300934 hasConceptScore W1972300934C156719811 @default.
• W1972300934 hasConceptScore W1972300934C159047783 @default.
• W1972300934 hasConceptScore W1972300934C16184334 @default.
• W1972300934 hasConceptScore W1972300934C179926584 @default.
• W1972300934 hasConceptScore W1972300934C199491388 @default.
• W1972300934 hasConceptScore W1972300934C2522874641 @default.
• W1972300934 hasConceptScore W1972300934C41895202 @default.
• W1972300934 hasConceptScore W1972300934C54355233 @default.
• W1972300934 hasConceptScore W1972300934C552990157 @default.
• W1972300934 hasConceptScore W1972300934C55493867 @default.
• W1972300934 hasConceptScore W1972300934C67705224 @default.
• W1972300934 hasConceptScore W1972300934C86803240 @default.
• W1972300934 hasIssue "11" @default.
• W1972300934 hasLocation W19723009341 @default.
• W1972300934 hasLocation W19723009342 @default.
• W1972300934 hasLocation W19723009343 @default.
• W1972300934 hasLocation W19723009344 @default.
• W1972300934 hasOpenAccess W1972300934 @default.
• W1972300934 hasPrimaryLocation W19723009341 @default.
• W1972300934 hasRelatedWork W100888133 @default.
• W1972300934 hasRelatedWork W1972300934 @default.

• next