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• W1972304476 abstract "LETTERS TO THE EDITORAdiponectin and inflammationGiamila FantuzziGiamila FantuzziPublished Online:01 Feb 2009https://doi.org/10.1152/ajpendo.90827.2008MoreSectionsPDF (29 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat to the editor: I am writing concerning the article “Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality” by Teoh et al. (4). In the abstract, results, and discussion of the paper, the authors repeatedly assert that thioglycollate-injected adiponectin-knockout [APN-KO (in Ref. 4 Adipoq−/−)] mice have a “markedly greater” neutrophilic infiltrate in the peritoneal cavity and a “significantly greater” cytokine production compared with wild-type (WT) mice. However, the figures showing these data (Figs. 2 and 4 in Ref. 4) do not support these claims. In fact, no statistical significance is reported between thioglycollate-injected WT and APN-KO mice for either neutrophil numbers or cytokine levels. The graph bars seem to indicate that indeed the difference is not significant, perhaps with the exception of IL-12. Therefore, it appears incorrect to state that APN deficiency elicits “a heightened inflammatory response to thioglycollate-induced peritonitis,” as the authors do in the discussion. The results by Teoh et al. are actually in agreement with our recent data obtained in the closely related model of zymosan-induced peritonitis, in which we demonstrate that APN-KO mice have a response comparable to that of WT mice in terms of cytokine production and minor differences in terms of cellular infiltrate (3).Furthermore, Teoh et al. demonstrate that administration of recombinant mouse (rm)APN reduces inflammatory infiltrate and cytokine production in both WT and APN KO mice (Figs. 2 and 4 in Ref. 4). However, data presented on page E661 indicate that administration of rmAPN to WT mice did not increase circulating APN levels. Moreover, APN-KO mice injected with rmAPN had less than 50% serum APN compared with WT mice and yet had significantly lower inflammation than WT mice. Therefore, there seems to be no correlation between the the anti-inflammatory effects of rmAPN and its ability to raise circulating APN levels. This observation, together with data presented in their Figs. 2 and 4, appears to indicate that APN is not directly involved in regulating cytokine production and neutrophilic infiltrate in response to thioglycollate and that protection afforded by administration of rmAPN may be attributable to a nonspecific effect.Since the role of APN as a regulator of inflammation is currently the subject of debate (1, 2), it important that data on this topic be presented and discussed in an accurate fashion to reflect the actual obervations.REFERENCES1 Fantuzzi G. Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol 121: 326–330, 2008.Crossref | PubMed | ISI | Google Scholar2 Lago F, Dieguez C, Gómez-Reino J, Gualillo O. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 3: 716–724, 2007.Crossref | PubMed | Google Scholar3 Pini M, Gove ME, Sennello JA, van Baal JW, Chan L, Fantuzzi G. Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice. Endocrinology 149: 4080–4085, 2008.Crossref | PubMed | ISI | Google Scholar4 Teoh H, Quan A, Bang KW, Wang G, Lovren F, Vu V, Haitsma JJ, Szmitko PE, Al-Omran M, Wang CH, Gupta M, Peterson MD, Zhang H, Chan L, Freedman J, Sweeney G, Verma S. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab 295: E658–E664, 2008.Link | ISI | Google Scholar Download PDF Previous Back to Top Next FiguresReferencesRelatedInformationCited ByRole of Nutrition Support in Inflammatory Conditions28 March 2017 | Nutrition in Clinical Practice, Vol. 32, No. 3Successive Phases of the Metabolic Response to Stress25 March 2016Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients8 March 2014 | Journal of Nephrology, Vol. 27, No. 6Metabolic response to the stress of critical illnessBritish Journal of Anaesthesia, Vol. 113, No. 6Adiponectin levels in patients with psoriasis: A meta-analysis12 March 2013 | The Journal of Dermatology, Vol. 40, No. 6Adiponectin protects rat hippocampal neurons against excitotoxicity15 September 2010 | AGE, Vol. 33, No. 2 More from this issue > Volume 296Issue 2February 2009Pages E397-E397 Copyright & PermissionsCopyright © 2009 the American Physiological Societyhttps://doi.org/10.1152/ajpendo.90827.2008PubMed19171845History Published online 1 February 2009 Published in print 1 February 2009 Metrics" @default.
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