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• W1972304844 startingPage "e24525" @default.
• W1972304844 abstract "Individuals born very preterm (before 33 weeks of gestation, VPT) are at risk of damage to developing white matter, which may affect later cognition and behaviour.We used diffusion tensor MRI (DT-MRI) to assess white matter microstructure (fractional anisotropy; FA) in 80 VPT and 41 term-born individuals (mean age 19.1 years, range 17-22, and 18.5 years, range 17-22 years, respectively). VPT individuals were part of a 1982-1984 birth cohort which had been followed up since birth; term individuals were recruited by local press advertisement. General intellectual function, executive function and memory were assessed.The VPT group had reduced FA in four clusters, and increased FA in four clusters relative to the Term group, involving several association tracts of both hemispheres. Clusters of increased FA were associated with more severe neonatal brain injury in the VPT group. Clusters of reduced FA were associated with lower birth weight and perinatal hypoxia, and with reduced adult cognitive performance in the VPT group only.Alterations of white matter microstructure persist into adulthood in VPT individuals and are associated with cognitive function." @default.
• W1972304844 created "2016-06-24" @default.
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• W1972304844 date "2011-10-12" @default.
• W1972304844 modified "2023-10-18" @default.
• W1972304844 title "White Matter and Cognition in Adults Who Were Born Preterm" @default.
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• W1972304844 doi "https://doi.org/10.1371/journal.pone.0024525" @default.
• W1972304844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3192037" @default.
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