FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972306915> ?p ?o ?g. }

• W1972306915 endingPage "2029" @default.
• W1972306915 startingPage "2018" @default.
• W1972306915 abstract "Saccharomyces cerevisiae cells lacking Dot1 exhibit a complete loss of H3K79 methylation and defects in heterochromatin-mediated silencing. To further understand the mechanism of Dot1-mediated methylation, the substrate requirement of Dot1 was determined. This analysis found that Dot1 requires histone H4 for in vitro methyltransferase activity and the histone H4 tail for Dot1-mediated methylation in yeast. Mutational analyses demonstrated that the basic patch residues (R 17 H 18 R 19 ) of the histone H4 N-terminal tail are required for Dot1 methyltransferase activity in vitro as well as Dot1-mediated histone H3K79 methylation in vivo. In vitro binding assays show that Dot1 can interact with the H4 N-terminal tail via the basic patch residues. Furthermore, an acidic patch at the C terminus of Dot1 is required for histone H4 tail binding in vitro, histone H3K79 di- and trimethylation in vivo, and proper telomere silencing. Our data suggest a novel trans -histone regulatory pathway whereby charged residues of one histone are required for the modification of another histone. These findings not only provide key insights into the mechanism of Dot1 histone methylation but also illustrate how chromatin-modifying enzymes engage their nucleosomal substrates in vivo." @default.
• W1972306915 created "2016-06-24" @default.
• W1972306915 creator A5056204856 @default.
• W1972306915 creator A5071371374 @default.
• W1972306915 creator A5075155830 @default.
• W1972306915 date "2007-08-03" @default.
• W1972306915 modified "2023-10-14" @default.
• W1972306915 title "A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new <i>trans</i>-histone pathway" @default.
• W1972306915 cites W159748353 @default.
• W1972306915 cites W1597773685 @default.
• W1972306915 cites W1963996414 @default.
• W1972306915 cites W1965343063 @default.
• W1972306915 cites W1969322634 @default.
• W1972306915 cites W1975518168 @default.
• W1972306915 cites W1976172452 @default.
• W1972306915 cites W1979157667 @default.
• W1972306915 cites W1982315838 @default.
• W1972306915 cites W1989092936 @default.
• W1972306915 cites W1995111407 @default.
• W1972306915 cites W1999723663 @default.
• W1972306915 cites W1999781198 @default.
• W1972306915 cites W2007984040 @default.
• W1972306915 cites W2016546870 @default.
• W1972306915 cites W2018663197 @default.
• W1972306915 cites W2022936129 @default.
• W1972306915 cites W2024584416 @default.
• W1972306915 cites W2036479240 @default.
• W1972306915 cites W2039940539 @default.
• W1972306915 cites W2042487483 @default.
• W1972306915 cites W2042600598 @default.
• W1972306915 cites W2059180978 @default.
• W1972306915 cites W2061167499 @default.
• W1972306915 cites W2073606168 @default.
• W1972306915 cites W2083248748 @default.
• W1972306915 cites W2092368988 @default.
• W1972306915 cites W2096083625 @default.
• W1972306915 cites W2096596194 @default.
• W1972306915 cites W2099565612 @default.
• W1972306915 cites W2100285856 @default.
• W1972306915 cites W2104082208 @default.
• W1972306915 cites W2106802219 @default.
• W1972306915 cites W2108014213 @default.
• W1972306915 cites W2111178066 @default.
• W1972306915 cites W2129208603 @default.
• W1972306915 cites W2144792857 @default.
• W1972306915 cites W2150715835 @default.
• W1972306915 cites W2151243189 @default.
• W1972306915 cites W2156222068 @default.
• W1972306915 cites W2156371750 @default.
• W1972306915 cites W2156465196 @default.
• W1972306915 cites W2156773083 @default.
• W1972306915 cites W2159952125 @default.
• W1972306915 cites W2172290898 @default.
• W1972306915 doi "https://doi.org/10.1101/gad.1560607" @default.
• W1972306915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1948857" @default.
• W1972306915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17675446" @default.
• W1972306915 hasPublicationYear "2007" @default.
• W1972306915 type Work @default.
• W1972306915 sameAs 1972306915 @default.
• W1972306915 citedByCount "121" @default.
• W1972306915 countsByYear W19723069152012 @default.
• W1972306915 countsByYear W19723069152013 @default.
• W1972306915 countsByYear W19723069152014 @default.
• W1972306915 countsByYear W19723069152015 @default.
• W1972306915 countsByYear W19723069152016 @default.
• W1972306915 countsByYear W19723069152017 @default.
• W1972306915 countsByYear W19723069152018 @default.
• W1972306915 countsByYear W19723069152019 @default.
• W1972306915 countsByYear W19723069152020 @default.
• W1972306915 countsByYear W19723069152021 @default.
• W1972306915 countsByYear W19723069152022 @default.
• W1972306915 countsByYear W19723069152023 @default.
• W1972306915 crossrefType "journal-article" @default.
• W1972306915 hasAuthorship W1972306915A5056204856 @default.
• W1972306915 hasAuthorship W1972306915A5071371374 @default.
• W1972306915 hasAuthorship W1972306915A5075155830 @default.
• W1972306915 hasBestOaLocation W19723069151 @default.
• W1972306915 hasConcept C10058791 @default.
• W1972306915 hasConcept C101152365 @default.
• W1972306915 hasConcept C104317684 @default.
• W1972306915 hasConcept C150194340 @default.
• W1972306915 hasConcept C150425827 @default.
• W1972306915 hasConcept C153911025 @default.
• W1972306915 hasConcept C190727270 @default.
• W1972306915 hasConcept C22709980 @default.
• W1972306915 hasConcept C2776745794 @default.
• W1972306915 hasConcept C2779085176 @default.
• W1972306915 hasConcept C50171091 @default.
• W1972306915 hasConcept C54355233 @default.
• W1972306915 hasConcept C552990157 @default.
• W1972306915 hasConcept C56428682 @default.
• W1972306915 hasConcept C64927066 @default.
• W1972306915 hasConcept C84772758 @default.
• W1972306915 hasConcept C86803240 @default.
• W1972306915 hasConceptScore W1972306915C10058791 @default.
• W1972306915 hasConceptScore W1972306915C101152365 @default.
• W1972306915 hasConceptScore W1972306915C104317684 @default.
• W1972306915 hasConceptScore W1972306915C150194340 @default.

• next