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- W1972311726 abstract "The effects of some slow channel blocking drugs were investigated on high affinity serotonin uptake into crude rat brain synaptosomes. Serotonin uptake was sodium-dependent and competitively inhibited by imipramine (IC 50 0.6 μM, K i 0.26 μM). Bepridil, verapamil and diltiazem produced an apparent competitive inhibition of serotonin uptake with respective IC 50 of 4.8, 5.2 and 308 μM. Nitrendipine and the sodium channel blocker, lidocaine, were without effect, even at 100 μM. The mechanism of the inhibitory effect is unknown but may involve an allosteric interaction with the sodium-dependent transporter." @default.
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- W1972311726 date "1986-04-01" @default.
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- W1972311726 title "The effects of some slow channel blocking drugs on high affinity serotonin uptake by rat brain synaptosomes" @default.
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- W1972311726 doi "https://doi.org/10.1016/0014-2999(86)90700-4" @default.
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