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• W1972313449 endingPage "155" @default.
• W1972313449 startingPage "155" @default.
• W1972313449 abstract "Purpose.: To investigate the therapeutic effect of topical adiponectin in a mouse model of experimental dry eye (EDE). Methods.: EDE was created by desiccating stress in 6- to 8-week old female C57BL/6 mice. Eye drops consisting of 0.0001%, 0.001%, or 0.01% adiponectin, or balanced salt solution (BSS), were applied in EDE. Tear volume and corneal irregularity score were measured at 5 and 10 days after treatment. Levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and monokine induced by interferon-γ (MIG) were measured in the conjunctiva and lacrimal gland using a multiplex immunobead assay at 10 days. Periodic acid–Schiff staining, immunohistochemistry, and flow cytometry were also performed. Results.: Mice treated with 0.001% or 0.01% adiponectin showed a significant improvement in tear volume and corneal irregularity compared with the EDE control and BSS-treated groups. A significant decrease in the levels of IL-1β, IL-6, TNF-α, IFN-γ, and MIG and staining intensity of TNF-α was observed in the 0.001% and 0.01% adiponectin-treated groups, compared with the other groups, in the conjunctiva and lacrimal gland. In the 0.001% and 0.01% adiponectin-treated groups, the density of conjunctival goblet cells was higher and the number of CD4+CXCR3+ T cells was lower than in the other groups. However, there were no significant differences in all parameters between the 0.0001% adiponectin and control groups. Conclusions.: Topical application of adiponectin can markedly improve clinical signs and decrease inflammation in the ocular surface and lacrimal gland of EDE, suggesting that adiponectin eye drops may be used as a therapeutic agent for dry eye disease." @default.
• W1972313449 created "2016-06-24" @default.
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• W1972313449 date "2013-01-07" @default.
• W1972313449 modified "2023-09-27" @default.
• W1972313449 title "Therapeutic Effect of Topical Adiponectin in a Mouse Model of Desiccating Stress–Induced Dry Eye" @default.
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• W1972313449 doi "https://doi.org/10.1167/iovs.12-10648" @default.
• W1972313449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23211823" @default.
• W1972313449 hasPublicationYear "2013" @default.
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