FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972315092> ?p ?o ?g. }

• W1972315092 endingPage "81" @default.
• W1972315092 startingPage "73" @default.
• W1972315092 abstract "The precise mechanism of the progression of advanced heart failure is unknown. We assessed a new scheme in two heart failure models: (I) congenital dilated cardiomyopathy (DCM) in TO-2 strain hamsters lacking delta-sarcoglycan (SG) gene and (II) administration of a high-dose of isoproterenol, as an acute heart failure in normal rats. In TO-2 hamsters, we followed the time course of the histological, physiological and metabolic the progressions of heart failure to the end stage. Dystrophin localization detected by immunostaining age-dependently to the myoplasm and the in situ sarcolemma fragility evaluated by Evans blue entry was increased in the same cardiomyocytes. Western blotting revealed a limited cleavage of the dystrophin protein at the rod domain, strongly suggesting a contribution of endogenous protease(s). We found a remarkable up-regulation of the amount of calpain-1 and -2, and no change of their counterpart, calpastatin. After supplementing TO-2 hearts with the normal delta-SG gene in vivo, these pathological alterations and the animals' survival improved. Furthermore, dystrophin but not delta-SG was disrupted by a high dose of isoproterenol, translocated from the sarcolemma to the myoplasm and fragmented. These results of heart failure, irrespective of the hereditary or acquired origin, indicate a vicious cycle formed by the increased sarcolemma permeability, preferential activation of calpain over calpastatin, and translocation and cleavage of dystrophin would commonly lead to advanced heart failure." @default.
• W1972315092 created "2016-06-24" @default.
• W1972315092 creator A5012439304 @default.
• W1972315092 creator A5014444085 @default.
• W1972315092 creator A5041063008 @default.
• W1972315092 creator A5068552779 @default.
• W1972315092 creator A5075000185 @default.
• W1972315092 creator A5078188464 @default.
• W1972315092 creator A5089051443 @default.
• W1972315092 date "2005-08-01" @default.
• W1972315092 modified "2023-10-09" @default.
• W1972315092 title "A novel scheme of dystrophin disruption for the progression of advanced heart failure" @default.
• W1972315092 cites W1519383882 @default.
• W1972315092 cites W1592908151 @default.
• W1972315092 cites W1593294300 @default.
• W1972315092 cites W1965858834 @default.
• W1972315092 cites W1975528602 @default.
• W1972315092 cites W1985292788 @default.
• W1972315092 cites W1985954761 @default.
• W1972315092 cites W1990177188 @default.
• W1972315092 cites W1991727391 @default.
• W1972315092 cites W2000439702 @default.
• W1972315092 cites W2026182775 @default.
• W1972315092 cites W2026699829 @default.
• W1972315092 cites W2042346825 @default.
• W1972315092 cites W2043879857 @default.
• W1972315092 cites W2053048384 @default.
• W1972315092 cites W2055054660 @default.
• W1972315092 cites W2056893352 @default.
• W1972315092 cites W2060148506 @default.
• W1972315092 cites W2060648861 @default.
• W1972315092 cites W2061393322 @default.
• W1972315092 cites W2065704959 @default.
• W1972315092 cites W2081925711 @default.
• W1972315092 cites W2084725634 @default.
• W1972315092 cites W2086701479 @default.
• W1972315092 cites W2098016509 @default.
• W1972315092 cites W2106086716 @default.
• W1972315092 cites W2118460319 @default.
• W1972315092 cites W2119951665 @default.
• W1972315092 cites W2120337309 @default.
• W1972315092 cites W2121779882 @default.
• W1972315092 cites W2123484022 @default.
• W1972315092 cites W2129967926 @default.
• W1972315092 cites W2138354938 @default.
• W1972315092 cites W2147609070 @default.
• W1972315092 cites W2154736819 @default.
• W1972315092 cites W2169867656 @default.
• W1972315092 cites W2312997470 @default.
• W1972315092 cites W2315633478 @default.
• W1972315092 cites W2317234192 @default.
• W1972315092 cites W2318480619 @default.
• W1972315092 cites W3023522280 @default.
• W1972315092 cites W4238376026 @default.
• W1972315092 doi "https://doi.org/10.1016/j.bbapap.2005.01.001" @default.
• W1972315092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16054019" @default.
• W1972315092 hasPublicationYear "2005" @default.
• W1972315092 type Work @default.
• W1972315092 sameAs 1972315092 @default.
• W1972315092 citedByCount "31" @default.
• W1972315092 countsByYear W19723150922012 @default.
• W1972315092 countsByYear W19723150922013 @default.
• W1972315092 countsByYear W19723150922014 @default.
• W1972315092 countsByYear W19723150922015 @default.
• W1972315092 countsByYear W19723150922016 @default.
• W1972315092 countsByYear W19723150922017 @default.
• W1972315092 countsByYear W19723150922018 @default.
• W1972315092 countsByYear W19723150922021 @default.
• W1972315092 countsByYear W19723150922022 @default.
• W1972315092 countsByYear W19723150922023 @default.
• W1972315092 crossrefType "journal-article" @default.
• W1972315092 hasAuthorship W1972315092A5012439304 @default.
• W1972315092 hasAuthorship W1972315092A5014444085 @default.
• W1972315092 hasAuthorship W1972315092A5041063008 @default.
• W1972315092 hasAuthorship W1972315092A5068552779 @default.
• W1972315092 hasAuthorship W1972315092A5075000185 @default.
• W1972315092 hasAuthorship W1972315092A5078188464 @default.
• W1972315092 hasAuthorship W1972315092A5089051443 @default.
• W1972315092 hasConcept C126322002 @default.
• W1972315092 hasConcept C134018914 @default.
• W1972315092 hasConcept C164705383 @default.
• W1972315092 hasConcept C181199279 @default.
• W1972315092 hasConcept C185592680 @default.
• W1972315092 hasConcept C199096232 @default.
• W1972315092 hasConcept C207200792 @default.
• W1972315092 hasConcept C2777488010 @default.
• W1972315092 hasConcept C2778198053 @default.
• W1972315092 hasConcept C2778943923 @default.
• W1972315092 hasConcept C2780394045 @default.
• W1972315092 hasConcept C55493867 @default.
• W1972315092 hasConcept C56928146 @default.
• W1972315092 hasConcept C71924100 @default.
• W1972315092 hasConcept C86803240 @default.
• W1972315092 hasConcept C95444343 @default.
• W1972315092 hasConceptScore W1972315092C126322002 @default.
• W1972315092 hasConceptScore W1972315092C134018914 @default.
• W1972315092 hasConceptScore W1972315092C164705383 @default.
• W1972315092 hasConceptScore W1972315092C181199279 @default.

• next