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• W1972324310 startingPage "182" @default.
• W1972324310 abstract "Certain metals that are necessary for regulating biological function at trace levels hold the potential to become neurotoxic when in excess. Specifically, chronic exposure to high levels of manganese leads to manganism, a neurological disorder that exhibits both motor and learning deficits similar to Parkinson's disease. Since Parkinson's disease symptomatology is primarily attributed to dopamine neurodegeneration in the striatum, dopamine system dysfunction has been implicated in the onset of manganism. In this study, dopamine system function in the dorsal striatum was evaluated in C57Bl/6 mice, 1, 7, and 21 days following repeated injections of manganese(II) chloride (50 mg/kg, subcutaneous) intermittently for 7 days. Tissue content analysis confirmed the presence of persistent accumulation of manganese in the striatum up to 21 days after cessation of treatment. In vitro fast scan cyclic voltammetry examined the effect of sub-acute manganese on electrically stimulated dopamine release and uptake in the striatum. While no difference was observed in uptake rates following manganese treatment, dopamine release was attenuated on days 7 and 21, compared to control levels. Basal levels of extracellular dopamine determined by the zero net flux microdialysis method were significantly lower in manganese-treated mice at 7 days post-treatment. On the other hand, potassium stimulated increases in extracellular dopamine were attenuated at all three time points. Together, these findings indicate that repeated manganese exposure has long-term effects on the regulation of exocytotic dopamine release in the striatum, which may be involved in the mechanism underlying manganese toxicity." @default.
• W1972324310 created "2016-06-24" @default.
• W1972324310 creator A5006597448 @default.
• W1972324310 creator A5027844507 @default.
• W1972324310 creator A5089843304 @default.
• W1972324310 date "2011-11-01" @default.
• W1972324310 modified "2023-10-10" @default.
• W1972324310 title "Altered striatal dopamine release following a sub-acute exposure to manganese" @default.
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• W1972324310 cites W1599299698 @default.
• W1972324310 cites W1963795300 @default.
• W1972324310 cites W1966737643 @default.
• W1972324310 cites W1972402291 @default.
• W1972324310 cites W1972741972 @default.
• W1972324310 cites W1974622545 @default.
• W1972324310 cites W1975707153 @default.
• W1972324310 cites W1977030972 @default.
• W1972324310 cites W1979944790 @default.
• W1972324310 cites W1980498101 @default.
• W1972324310 cites W1980592214 @default.
• W1972324310 cites W1983210731 @default.
• W1972324310 cites W1984726456 @default.
• W1972324310 cites W1985223881 @default.
• W1972324310 cites W1990049827 @default.
• W1972324310 cites W1990063008 @default.
• W1972324310 cites W1990567511 @default.
• W1972324310 cites W1991526747 @default.
• W1972324310 cites W1991932326 @default.
• W1972324310 cites W1995840214 @default.
• W1972324310 cites W1996867268 @default.
• W1972324310 cites W1997410074 @default.
• W1972324310 cites W1998271947 @default.
• W1972324310 cites W2001003591 @default.
• W1972324310 cites W2004196774 @default.
• W1972324310 cites W2004714156 @default.
• W1972324310 cites W2007304000 @default.
• W1972324310 cites W2009133337 @default.
• W1972324310 cites W2009573330 @default.
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• W1972324310 cites W2010413751 @default.
• W1972324310 cites W2018634009 @default.
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• W1972324310 cites W2025791859 @default.
• W1972324310 cites W2028680240 @default.
• W1972324310 cites W2029649014 @default.
• W1972324310 cites W2036743234 @default.
• W1972324310 cites W2038874217 @default.
• W1972324310 cites W2039562961 @default.
• W1972324310 cites W2041158250 @default.
• W1972324310 cites W2042436759 @default.
• W1972324310 cites W2048960021 @default.
• W1972324310 cites W2049156933 @default.
• W1972324310 cites W2053868891 @default.
• W1972324310 cites W2054439814 @default.
• W1972324310 cites W2055584145 @default.
• W1972324310 cites W2059082210 @default.
• W1972324310 cites W2060458138 @default.
• W1972324310 cites W2061369440 @default.
• W1972324310 cites W2064257351 @default.
• W1972324310 cites W2065665126 @default.
• W1972324310 cites W2069049686 @default.
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• W1972324310 cites W2085016142 @default.
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• W1972324310 cites W2106926426 @default.
• W1972324310 cites W2109669266 @default.
• W1972324310 cites W2112648950 @default.
• W1972324310 cites W2120968628 @default.
• W1972324310 cites W2124256563 @default.
• W1972324310 cites W2125407940 @default.
• W1972324310 cites W2129352725 @default.
• W1972324310 cites W2130202356 @default.
• W1972324310 cites W2135655848 @default.
• W1972324310 cites W2138888765 @default.
• W1972324310 cites W2141490434 @default.
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• W1972324310 doi "https://doi.org/10.1016/j.jneumeth.2011.06.019" @default.
• W1972324310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21740928" @default.
• W1972324310 hasPublicationYear "2011" @default.
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