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- W1972327627 abstract "Purpose To assess the relation between the intraocular pressure-lowering efficacy of latanoprost 0.005% and the area of the ciliary body face exposed to the anterior chamber as assessed by ultrasound biomicroscopy. Patients and Methods Untreated, latanoprost-naive patients with ocular hypertension or open-angle glaucoma were enrolled in this prospective clinical trial. A radial, perpendicular ultrasound biomicroscopy image at the 6-o'clock position detailing Schwalbe line, scleral spur, and iris insertion was obtained. The distances between these structures were then measured and their relations to the intraocular pressure-lowering effect of latanoprost at 1, 2, 3, and 6 months were analyzed. Results Fifty-four eyes (54 patients) were enrolled. The mean age of participants was 60.2 ± 13.9 years, and mean pretreatment intraocular pressure was 26.4 ± 3.8 mm Hg. The mean intraocular pressure reduction from baseline was 7.1 mm Hg (26.9%), 7.3 (27.7%), 7.8 (29.5%), and 7.7 (29.2%) at 1, 2, 3 and 6 months, respectively. The mean distance between the scleral spur and the iris insertion was 0.14 ± 0.08 mm (range, 0.04–0.33 mm). There was a significant correlation between intraocular pressure reduction at 1 month and trabecular meshwork height, suggesting that intraocular pressure reduction was associated with increasing trabecular meshwork height (P < 0.05). No other correlation could be found regarding intraocular pressure reduction. Conclusion Although latanoprost lowers intraocular pressure by enhancing uveoscleral outflow, its efficacy is independent of the height of the ciliary face." @default.
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- W1972327627 date "2002-06-01" @default.
- W1972327627 modified "2023-09-23" @default.
- W1972327627 title "The Efficacy of Latanoprost is Independent of the Width of the Ciliary Body Face" @default.
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- W1972327627 doi "https://doi.org/10.1097/00061198-200206000-00013" @default.
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