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• W1972327928 abstract "Slowness of goal-directed movements is a frequent symptom following cerebellar lesions. So far it has not been demonstrated whether this slowness represents compensation for impaired braking which is a feature of cerebellar dysfunction with the consequence of hypermetria, or whether it is an independent part of cerebellar movement disorder. To resolve this question we tested 18 cerebellar patients in a paradigm where they not only had to perform fast goal-directed wrist flexion movements (amplitudes 5° and 30°) but also wrist flexion movements as fast and large as possible without particular target. In normals antagonist activity is minimal in large movements without target. Although subjects were clinically only mildly affected they regularly showed a ‘slowness of movement’ resulting from a reduction of peak acceleration. This in turn was due to the reduced generation of agonist activity. Peak velocity was not significantly decreased because the acceleration phase was adequately prolonged. Since these changes were most pronounced in the ‘fast’ movements without target the compensation hypothesis should be discarded. The reduction of acceleration must at least partially be due to a genuine cerebellar deficiency in the fast generation of agonist activity." @default.
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• W1972327928 date "1996-03-01" @default.
• W1972327928 modified "2023-09-24" @default.
• W1972327928 title "Acceleration deficit in patients with cerebellar lesions. A study of kinematic and EMG-parameters in fast wrist movements" @default.
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• W1972327928 doi "https://doi.org/10.1016/0006-8993(95)01514-0" @default.
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