FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972348007> ?p ?o ?g. }

• W1972348007 endingPage "318" @default.
• W1972348007 startingPage "311" @default.
• W1972348007 abstract "IL6(T23)-PE38KDEL is a chimeric molecule composed of interleukin 6 (IL6), missing the N-terminal 23 amino acids, and fused to a truncated mutant form of Pseudomonas exotoxin (PE38KDEL). The aim of this study was to evaluate this recombinant immunotoxin in terms of its specific cytotoxicity to IL6R-overexpressing multiple myeloma (MM) cells in vitro, as well as its antitumor effects and side effects in vivo. IL6(T23)-PE38KDEL was expressed in Escherichia coli, refolded and purified from inclusion bodies. The purified IL6(T23)-PE38KDEL was found to be selectively cytotoxic to IL6 receptor-positive tumor cells in vitro. IC(50) values of IL6(T23)-PE38KDEL were evaluated by MTS assay. Toxicity and maximum-tolerated dose of IL6(T23)-PE38KDEL were determined in mice. The antitumor activity of IL6(T23)-PE38KDEL was evaluated in mice with MM through intravenous injection and interventional therapy. Intravenous administration of IL6(T23)-PE38KDEL caused a significantly increased survival time in treated mice, and exhibited dose- and time-dependent antitumor effects against MM mice. Moreover, complete tumor regression was observed in 30 and 80% of mice treated intravenously and intraperitoneally, respectively, with 0.4 mg/kg/day for 10 days. These results demonstrated that the recombinant immunotoxin IL6(T23)-PE38KDEL kills IL6R-overexpressing cancer cells, and causes significant tumor regression." @default.
• W1972348007 created "2016-06-24" @default.
• W1972348007 creator A5018441372 @default.
• W1972348007 creator A5039524690 @default.
• W1972348007 creator A5063071550 @default.
• W1972348007 creator A5080176831 @default.
• W1972348007 creator A5089470126 @default.
• W1972348007 creator A5089902368 @default.
• W1972348007 date "2012-05-25" @default.
• W1972348007 modified "2023-10-01" @default.
• W1972348007 title "In vitro and in vivo antitumor effects of the recombinant immunotoxin IL6(T23)-PE38KDEL in multiple myeloma" @default.
• W1972348007 cites W125160567 @default.
• W1972348007 cites W1493004097 @default.
• W1972348007 cites W1550052423 @default.
• W1972348007 cites W1592761587 @default.
• W1972348007 cites W1597531891 @default.
• W1972348007 cites W1652153701 @default.
• W1972348007 cites W1671275184 @default.
• W1972348007 cites W1886985639 @default.
• W1972348007 cites W1964122042 @default.
• W1972348007 cites W1968365367 @default.
• W1972348007 cites W1969791558 @default.
• W1972348007 cites W1972719386 @default.
• W1972348007 cites W1974043792 @default.
• W1972348007 cites W1983016106 @default.
• W1972348007 cites W1990761369 @default.
• W1972348007 cites W1991441002 @default.
• W1972348007 cites W1995702041 @default.
• W1972348007 cites W2004490137 @default.
• W1972348007 cites W2009013652 @default.
• W1972348007 cites W2017676455 @default.
• W1972348007 cites W2018210389 @default.
• W1972348007 cites W2020119933 @default.
• W1972348007 cites W2021510332 @default.
• W1972348007 cites W2022969414 @default.
• W1972348007 cites W2042166361 @default.
• W1972348007 cites W2044577790 @default.
• W1972348007 cites W2046961880 @default.
• W1972348007 cites W2047132026 @default.
• W1972348007 cites W2049762173 @default.
• W1972348007 cites W2053683318 @default.
• W1972348007 cites W2053950029 @default.
• W1972348007 cites W2060964376 @default.
• W1972348007 cites W2062085883 @default.
• W1972348007 cites W2063281625 @default.
• W1972348007 cites W2065423182 @default.
• W1972348007 cites W2067502344 @default.
• W1972348007 cites W2082540596 @default.
• W1972348007 cites W2092327903 @default.
• W1972348007 cites W2144762512 @default.
• W1972348007 cites W2147087898 @default.
• W1972348007 cites W2151480449 @default.
• W1972348007 cites W2155580583 @default.
• W1972348007 cites W2167868583 @default.
• W1972348007 cites W2168036974 @default.
• W1972348007 cites W2169802771 @default.
• W1972348007 cites W2171418910 @default.
• W1972348007 cites W2398247158 @default.
• W1972348007 cites W2407947355 @default.
• W1972348007 cites W2428993875 @default.
• W1972348007 cites W3190406687 @default.
• W1972348007 cites W342350979 @default.
• W1972348007 cites W7092856 @default.
• W1972348007 doi "https://doi.org/10.3892/ol.2012.733" @default.
• W1972348007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3402730" @default.
• W1972348007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22844376" @default.
• W1972348007 hasPublicationYear "2012" @default.
• W1972348007 type Work @default.
• W1972348007 sameAs 1972348007 @default.
• W1972348007 citedByCount "7" @default.
• W1972348007 countsByYear W19723480072013 @default.
• W1972348007 countsByYear W19723480072014 @default.
• W1972348007 countsByYear W19723480072017 @default.
• W1972348007 countsByYear W19723480072018 @default.
• W1972348007 countsByYear W19723480072020 @default.
• W1972348007 crossrefType "journal-article" @default.
• W1972348007 hasAuthorship W1972348007A5018441372 @default.
• W1972348007 hasAuthorship W1972348007A5039524690 @default.
• W1972348007 hasAuthorship W1972348007A5063071550 @default.
• W1972348007 hasAuthorship W1972348007A5080176831 @default.
• W1972348007 hasAuthorship W1972348007A5089470126 @default.
• W1972348007 hasAuthorship W1972348007A5089902368 @default.
• W1972348007 hasBestOaLocation W19723480071 @default.
• W1972348007 hasConcept C109316439 @default.
• W1972348007 hasConcept C115085202 @default.
• W1972348007 hasConcept C150903083 @default.
• W1972348007 hasConcept C154317977 @default.
• W1972348007 hasConcept C182179738 @default.
• W1972348007 hasConcept C185592680 @default.
• W1972348007 hasConcept C202751555 @default.
• W1972348007 hasConcept C207001950 @default.
• W1972348007 hasConcept C55493867 @default.
• W1972348007 hasConcept C71924100 @default.
• W1972348007 hasConcept C86803240 @default.
• W1972348007 hasConcept C98274493 @default.
• W1972348007 hasConceptScore W1972348007C109316439 @default.
• W1972348007 hasConceptScore W1972348007C115085202 @default.
• W1972348007 hasConceptScore W1972348007C150903083 @default.

• next