FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972352278> ?p ?o ?g. }

• W1972352278 abstract "We present a quantitative comparison of continuous and pulsed spin labelling (CASL and FAIR respectively) in the mouse brain. The quantification of perfusion measurements is complicated by several physiological parameters such as the arterial transit time; also these parameters may change during abnormal conditions. The aim of this study is to compare the performance of the two sequences in mice, both for normal flow rates and during ischemia, when perfusion is low. Eight mice were anaesthetised and maintained on 1.3–1.7% isoflurane with 100% oxygen. The middle cerebral artery was occluded, and animals were scanned at 2 and 24 hours after occlusion. Coronal EPI images were obtained on a 2.35 T SMIS MRI scanner. FAIR: Short repetition time FAIR sequence 1, non-selective inversion or a selective FOCI inversion pulse, delay time 1300 ms, TR 1.5 s, and 22 averages. CASL: transit time insensitive CASL 2, interleaved adiabatic inversion labelling and control measurements, post-labelling delay time 500 ms, TR 1 s, and 22 averages. T1sat and T1 were also measured. Data processing: 4 ROIs were selected in each animal for further analysis. FAIR: the ssIR data were used to fit M0, T1app and a. These values were then used to fit the magnetisation difference for CBF 1. CASL: T1, T1sat and M0 were fitted using the IR data; subsequently these values were used to fit the magnetisation difference according to Alsop et al. 2 for CBF. FAIR was assumed to be transit time insensitive. For CASL: arterial transit time cortex 440 ms, basal ganglia 290 ms (previous results; data not shown). Transit time correction (see results): CASL: cortex 800 ms, basal ganglia 600 ms, based on previous rat studies 3. FAIR: cortex 500 ms, basal ganglia 500 ms. For normal perfusion rates (>100 ml/100g/min) there was an excellent correlation between the CASL and FAIR data (r = 0.96). The mean difference between the techniques was negligible, with a 95% confidence interval of -30 to +31 ml/100 g/min between the two methods for any given measurement. In the case of compromised CBF however, there was a marked discrepancy between the techniques, with FAIR showing little sensitivity to different flow rates, in agreement with earlier reports 1. This is most likely due to increased arterial transit times during occlusion, which would render the assumption that the technique is transit-time insensitive invalid. A transit time correction in the FAIR and CASL calculations for the ROIs with low CBF improved the correspondence between the techniques, though there was still a difference, indicating that either the FAIR transit time during occlusion is even larger than estimated, or there are other confounding factors influencing the measurement. Further studies using transit-time insensitive sequences such as multi-TI FAIR or QUIPSS II 4 are needed to investigate this phenomenon." @default.
• W1972352278 created "2016-06-24" @default.
• W1972352278 creator A5005420739 @default.
• W1972352278 creator A5030599902 @default.
• W1972352278 creator A5086704264 @default.
• W1972352278 creator A5087017337 @default.
• W1972352278 date "2005-08-01" @default.
• W1972352278 modified "2023-09-25" @default.
• W1972352278 title "A comparison of FAIR and CASL perfusion imaging in mice" @default.
• W1972352278 cites W1966930409 @default.
• W1972352278 cites W1994192509 @default.
• W1972352278 cites W2024824783 @default.
• W1972352278 doi "https://doi.org/10.1038/sj.jcbfm.9591524.0343" @default.
• W1972352278 hasPublicationYear "2005" @default.
• W1972352278 type Work @default.
• W1972352278 sameAs 1972352278 @default.
• W1972352278 citedByCount "0" @default.
• W1972352278 crossrefType "journal-article" @default.
• W1972352278 hasAuthorship W1972352278A5005420739 @default.
• W1972352278 hasAuthorship W1972352278A5030599902 @default.
• W1972352278 hasAuthorship W1972352278A5086704264 @default.
• W1972352278 hasAuthorship W1972352278A5087017337 @default.
• W1972352278 hasConcept C121332964 @default.
• W1972352278 hasConcept C126838900 @default.
• W1972352278 hasConcept C135691158 @default.
• W1972352278 hasConcept C146957229 @default.
• W1972352278 hasConcept C2989005 @default.
• W1972352278 hasConcept C3018723549 @default.
• W1972352278 hasConcept C33923547 @default.
• W1972352278 hasConcept C41008148 @default.
• W1972352278 hasConcept C46141821 @default.
• W1972352278 hasConcept C71924100 @default.
• W1972352278 hasConceptScore W1972352278C121332964 @default.
• W1972352278 hasConceptScore W1972352278C126838900 @default.
• W1972352278 hasConceptScore W1972352278C135691158 @default.
• W1972352278 hasConceptScore W1972352278C146957229 @default.
• W1972352278 hasConceptScore W1972352278C2989005 @default.
• W1972352278 hasConceptScore W1972352278C3018723549 @default.
• W1972352278 hasConceptScore W1972352278C33923547 @default.
• W1972352278 hasConceptScore W1972352278C41008148 @default.
• W1972352278 hasConceptScore W1972352278C46141821 @default.
• W1972352278 hasConceptScore W1972352278C71924100 @default.
• W1972352278 hasLocation W19723522781 @default.
• W1972352278 hasOpenAccess W1972352278 @default.
• W1972352278 hasPrimaryLocation W19723522781 @default.
• W1972352278 hasRelatedWork W2047521789 @default.
• W1972352278 hasRelatedWork W2353261520 @default.
• W1972352278 hasRelatedWork W2354358054 @default.
• W1972352278 hasRelatedWork W2356249032 @default.
• W1972352278 hasRelatedWork W2379953974 @default.
• W1972352278 hasRelatedWork W2382350448 @default.
• W1972352278 hasRelatedWork W2601229504 @default.
• W1972352278 hasRelatedWork W3030154407 @default.
• W1972352278 hasRelatedWork W3030614551 @default.
• W1972352278 hasRelatedWork W3032311490 @default.
• W1972352278 isParatext "false" @default.
• W1972352278 isRetracted "false" @default.
• W1972352278 magId "1972352278" @default.
• W1972352278 workType "article" @default.