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• W1972359298 abstract "Primary cilia and flagella are widely distinct structures with different function present in most of the eukaryotic cells. Despite they share similar basic organization and architecture, a direct developmental continuity among them has not been reported until now. The primary cilium is a dynamic structure that typically assembles and disassembles during mitotic cell cycles, whereas the sperm axoneme is nucleated by the centriole inherited by the differentiating spermatid at the end of meiosis. Fruit flies represent a remarkable exception to this general rule. Drosophila spermatocytes have an unusual axoneme-based structure reminiscent of primary cilia (here called cilium like region, or CLR). This structure persists through the meiotic divisions when it is internalized together with the centriole to organize the centrosome and is finally inherited by young spermatids. Examination of elongating spermatids by transmission electron microscopy (EM) and cold regrowth experiments suggests that the motile axoneme derives directly by the elongation and the remodelling of the immotile CLR. Both CLR and elongating spermatid flagella have incomplete C-tubules that form longitudinal sheets associated to the B-tubule wall, unlike axonemes of other organisms in which C-tubules stop growing at the transition between the basal body and the axonemal doublets. Moreover, both CLR and spermatid flagella lack a structured transition zone, a characteristic feature of ciliated cells. Uncoordinated (unc) mutants that lack C-remnants have short centrioles, suggesting that the C-sheets may play some roles in the elongation of the centriole after its docking to the cell membrane. In conclusion, the structural similarities between CLR and sperm axoneme suggest that the CLR may be considered the basal region of the future axoneme and may represent the start point for its elongation." @default.
• W1972359298 created "2016-06-24" @default.
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• W1972359298 date "2013-01-01" @default.
• W1972359298 modified "2023-10-13" @default.
• W1972359298 title "The cilium like region of the<i>Drosophila</i>spermatocyte: an oncoming flagellum?" @default.
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• W1972359298 doi "https://doi.org/10.1242/jcs.136523" @default.
• W1972359298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24105264" @default.
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