FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972363305> ?p ?o ?g. }

• W1972363305 endingPage "756" @default.
• W1972363305 startingPage "750" @default.
• W1972363305 abstract "Introduction In systemic endotoxaemia, bacterial lipopolysaccharide causes the rapid expression of tissue factor (TF) and disseminated intravascular coagulation and in animal models, anticoagulants limit pathology and promote survival. Recent studies have emphasised the importance of TF expressed by mononuclear cells for initiating thrombin generation during endotoxaemia and suggested that endothelial cell TF is of little relevance. However, the precise importance of endothelium for intravascular thrombin generation has not been established. In this study, we compared the effect of equivalent levels of hirudin tethered to either endothelium or platelets and monocytes. Materials and Methods CD31-Hir-Tg mice express a vesicle-targeted, membrane-tethered hirudin fusion protein on endothelium, platelets and monocytes. Bone marrow chimeras between these mice and C57BL/6 were generated The level of intravascular hirudin expressed during endotoxaemia was quantified by inhibition studies using an anti-hirudin antibody and reference to the circulating thrombin anti-thrombin complexes generated in control mice given soluble hirudin. Results and Conclusions Antibody inhibition studies indicated that individual chimeras expressed similar levels of hirudin fusion protein on endothelium alone as on platelets and leukocytes combined and accordingly, the levels of thrombin anti-thrombin complexes and fibrinogen in each chimera were similar, indicating equivalent inhibition of thrombin generation. However, mice with hirudin on endothelium alone developed significantly less thrombocytopenia. These results suggest a hitherto unrecognized role of endothelium in thrombin-dependent platelet sequestration during endotoxaemia. The data have implications for the development of therapeutic strategies based on targeted anticoagulation to limit disseminated intravascular coagulation." @default.
• W1972363305 created "2016-06-24" @default.
• W1972363305 creator A5002570839 @default.
• W1972363305 creator A5005958296 @default.
• W1972363305 creator A5089633744 @default.
• W1972363305 date "2013-12-01" @default.
• W1972363305 modified "2023-09-28" @default.
• W1972363305 title "Enhanced effect of inhibition of thrombin on endothelium in murine endotoxaemia: Specific inhibition of thrombocytopenia" @default.
• W1972363305 cites W127024949 @default.
• W1972363305 cites W1540403899 @default.
• W1972363305 cites W1544112473 @default.
• W1972363305 cites W1582902340 @default.
• W1972363305 cites W1964798946 @default.
• W1972363305 cites W1967057746 @default.
• W1972363305 cites W1979862980 @default.
• W1972363305 cites W1980877232 @default.
• W1972363305 cites W1983547075 @default.
• W1972363305 cites W1983760732 @default.
• W1972363305 cites W1983839376 @default.
• W1972363305 cites W1988697869 @default.
• W1972363305 cites W1995201515 @default.
• W1972363305 cites W1998518075 @default.
• W1972363305 cites W2007008943 @default.
• W1972363305 cites W2008372909 @default.
• W1972363305 cites W2015877067 @default.
• W1972363305 cites W2023122926 @default.
• W1972363305 cites W2029819859 @default.
• W1972363305 cites W2041288329 @default.
• W1972363305 cites W2044352498 @default.
• W1972363305 cites W2048496083 @default.
• W1972363305 cites W2048559240 @default.
• W1972363305 cites W2052792411 @default.
• W1972363305 cites W2053367545 @default.
• W1972363305 cites W2053568531 @default.
• W1972363305 cites W2078674461 @default.
• W1972363305 cites W2079383336 @default.
• W1972363305 cites W2086386188 @default.
• W1972363305 cites W2092178015 @default.
• W1972363305 cites W2092401570 @default.
• W1972363305 cites W2092583562 @default.
• W1972363305 cites W2108435955 @default.
• W1972363305 cites W2115301416 @default.
• W1972363305 cites W2118902632 @default.
• W1972363305 cites W2122433970 @default.
• W1972363305 cites W2125317149 @default.
• W1972363305 cites W2132577713 @default.
• W1972363305 cites W2137336518 @default.
• W1972363305 cites W2141868068 @default.
• W1972363305 cites W2142649232 @default.
• W1972363305 cites W2146601710 @default.
• W1972363305 cites W2161961353 @default.
• W1972363305 cites W2162292125 @default.
• W1972363305 cites W2165077166 @default.
• W1972363305 cites W2214759602 @default.
• W1972363305 cites W2223886345 @default.
• W1972363305 cites W2224814775 @default.
• W1972363305 cites W2322121630 @default.
• W1972363305 cites W2412312642 @default.
• W1972363305 cites W2485082676 @default.
• W1972363305 cites W2789655943 @default.
• W1972363305 cites W642310069 @default.
• W1972363305 cites W78534985 @default.
• W1972363305 doi "https://doi.org/10.1016/j.thromres.2013.10.002" @default.
• W1972363305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24161661" @default.
• W1972363305 hasPublicationYear "2013" @default.
• W1972363305 type Work @default.
• W1972363305 sameAs 1972363305 @default.
• W1972363305 citedByCount "3" @default.
• W1972363305 countsByYear W19723633052017 @default.
• W1972363305 countsByYear W19723633052018 @default.
• W1972363305 countsByYear W19723633052019 @default.
• W1972363305 crossrefType "journal-article" @default.
• W1972363305 hasAuthorship W1972363305A5002570839 @default.
• W1972363305 hasAuthorship W1972363305A5005958296 @default.
• W1972363305 hasAuthorship W1972363305A5089633744 @default.
• W1972363305 hasBestOaLocation W19723633052 @default.
• W1972363305 hasConcept C126322002 @default.
• W1972363305 hasConcept C144594695 @default.
• W1972363305 hasConcept C185592680 @default.
• W1972363305 hasConcept C186738567 @default.
• W1972363305 hasConcept C203014093 @default.
• W1972363305 hasConcept C2776992346 @default.
• W1972363305 hasConcept C2777292125 @default.
• W1972363305 hasConcept C2778271848 @default.
• W1972363305 hasConcept C2778382381 @default.
• W1972363305 hasConcept C2778734968 @default.
• W1972363305 hasConcept C54173615 @default.
• W1972363305 hasConcept C71924100 @default.
• W1972363305 hasConcept C89560881 @default.
• W1972363305 hasConcept C98274493 @default.
• W1972363305 hasConceptScore W1972363305C126322002 @default.
• W1972363305 hasConceptScore W1972363305C144594695 @default.
• W1972363305 hasConceptScore W1972363305C185592680 @default.
• W1972363305 hasConceptScore W1972363305C186738567 @default.
• W1972363305 hasConceptScore W1972363305C203014093 @default.
• W1972363305 hasConceptScore W1972363305C2776992346 @default.
• W1972363305 hasConceptScore W1972363305C2777292125 @default.
• W1972363305 hasConceptScore W1972363305C2778271848 @default.

• next