Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972371479> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1972371479 endingPage "474" @default.
- W1972371479 startingPage "463" @default.
- W1972371479 abstract "ThePatch(Ph) mutation in the mouse, a deletion that includes the gene for PDGFRα, is a recessive lethal that exhibits a dominant pigment phenotype in heterozygotes. To assess whether thePhmutation acts cell-autonomously or non-autonomously on melanocyte development, we have examined the melanogenic potential of neural crest populations from normal and mutant crest cellsin vitroand the pattern of dispersal and survival of melanocyte precursors (MPs)in vivo.We report that trunk neural crest cells from homozygousPhembryos give rise to pigmented melanocytesin vitroin response to Steel factor (SlF).In vivo,homozygousPhembryos contain a subpopulation of crest-derived cells that express c-kit and tyrosinase-related protein-2 characteristic of MPs. These cells begin to migrate normally on the lateral crest migration pathway, but then fail to disperse in the dermal mesenchyme and subsequently disappear. Although dermal mesenchyme is adversely affected inPhhomozygotes, SlF mRNA expression by the cells of the dermatome is normal inPhembryos when neural crest-derived MPs start to migrate on the lateral pathway. In contrast, mRNA for the SlF receptor, c-kit, was observed to be ectopically expressed in somites and lateral mesenchyme in embryos carrying thePhmutation. Based on this ectopic expression of c-kit inPhmutant embryos, and the observed distribution of SlF protein in normal and mutant embryos, we suggest that competition for limited amounts of SlF localized on the lateral neural crest migration pathway alters melanocyte dispersal and survival." @default.
- W1972371479 created "2016-06-24" @default.
- W1972371479 creator A5017417786 @default.
- W1972371479 creator A5040676669 @default.
- W1972371479 creator A5064918956 @default.
- W1972371479 date "1996-08-01" @default.
- W1972371479 modified "2023-10-09" @default.
- W1972371479 title "Ectopic c-kit Expression Affects the Fate of Melanocyte Precursors in Patch Mutant Embryos" @default.
- W1972371479 cites W1794896472 @default.
- W1972371479 cites W2037010084 @default.
- W1972371479 cites W2112811492 @default.
- W1972371479 doi "https://doi.org/10.1006/dbio.1996.0178" @default.
- W1972371479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8806824" @default.
- W1972371479 hasPublicationYear "1996" @default.
- W1972371479 type Work @default.
- W1972371479 sameAs 1972371479 @default.
- W1972371479 citedByCount "50" @default.
- W1972371479 countsByYear W19723714792014 @default.
- W1972371479 countsByYear W19723714792015 @default.
- W1972371479 countsByYear W19723714792018 @default.
- W1972371479 countsByYear W19723714792022 @default.
- W1972371479 crossrefType "journal-article" @default.
- W1972371479 hasAuthorship W1972371479A5017417786 @default.
- W1972371479 hasAuthorship W1972371479A5040676669 @default.
- W1972371479 hasAuthorship W1972371479A5064918956 @default.
- W1972371479 hasBestOaLocation W19723714791 @default.
- W1972371479 hasConcept C104317684 @default.
- W1972371479 hasConcept C126749454 @default.
- W1972371479 hasConcept C143065580 @default.
- W1972371479 hasConcept C196843134 @default.
- W1972371479 hasConcept C2776340970 @default.
- W1972371479 hasConcept C2777658100 @default.
- W1972371479 hasConcept C2779769559 @default.
- W1972371479 hasConcept C2780071072 @default.
- W1972371479 hasConcept C54355233 @default.
- W1972371479 hasConcept C81885089 @default.
- W1972371479 hasConcept C86803240 @default.
- W1972371479 hasConcept C95444343 @default.
- W1972371479 hasConcept C97037327 @default.
- W1972371479 hasConceptScore W1972371479C104317684 @default.
- W1972371479 hasConceptScore W1972371479C126749454 @default.
- W1972371479 hasConceptScore W1972371479C143065580 @default.
- W1972371479 hasConceptScore W1972371479C196843134 @default.
- W1972371479 hasConceptScore W1972371479C2776340970 @default.
- W1972371479 hasConceptScore W1972371479C2777658100 @default.
- W1972371479 hasConceptScore W1972371479C2779769559 @default.
- W1972371479 hasConceptScore W1972371479C2780071072 @default.
- W1972371479 hasConceptScore W1972371479C54355233 @default.
- W1972371479 hasConceptScore W1972371479C81885089 @default.
- W1972371479 hasConceptScore W1972371479C86803240 @default.
- W1972371479 hasConceptScore W1972371479C95444343 @default.
- W1972371479 hasConceptScore W1972371479C97037327 @default.
- W1972371479 hasIssue "2" @default.
- W1972371479 hasLocation W19723714791 @default.
- W1972371479 hasLocation W19723714792 @default.
- W1972371479 hasOpenAccess W1972371479 @default.
- W1972371479 hasPrimaryLocation W19723714791 @default.
- W1972371479 hasRelatedWork W155246264 @default.
- W1972371479 hasRelatedWork W1871458241 @default.
- W1972371479 hasRelatedWork W1983082939 @default.
- W1972371479 hasRelatedWork W1995511868 @default.
- W1972371479 hasRelatedWork W2022841252 @default.
- W1972371479 hasRelatedWork W2022853418 @default.
- W1972371479 hasRelatedWork W2032054876 @default.
- W1972371479 hasRelatedWork W2949638377 @default.
- W1972371479 hasRelatedWork W3002383470 @default.
- W1972371479 hasRelatedWork W4362636161 @default.
- W1972371479 hasVolume "177" @default.
- W1972371479 isParatext "false" @default.
- W1972371479 isRetracted "false" @default.
- W1972371479 magId "1972371479" @default.
- W1972371479 workType "article" @default.